Our paper Comparing and Contrasting A Priori and A Posteriori Generalizability Assessment of Clinical Trials on Type 2 Diabetes Mellitus won one of the Distinguished Paper Awards of the American Medical Informatics Association 2017 Annual Symposium. Congratulations to Arturo for his great work!.
Many congratulations to Vaclav Papez who successfully defended his thesis and was awarded his PhD on: Archetype-based approach for modelling of electroencephalographic/event-related potentials data and metadata.
Many congratulations to Marina Daskalopoulou who successfully defended her thesis and was awarded her PhD on: Sexual behaviour of HIV-diagnosed men who have sex with men in the current era of effective antiretroviral therapy in the UK.
The ability of external investigators to reproduce published scientific findings is critical for the evaluation and validation of biomedical research by the wider community. However, a substantial proportion of health research using electronic health records (EHR), data collected and generated during clinical care, is potentially not reproducible mainly due to the fact that the implementation details of most data preprocessing, cleaning, phenotyping and analysis approaches are not systematically made available or shared. Our work outlines a collection of methods and tools from adjunct scientific disciplines that can potentially enable the reproducibility of EHR research findings.
Congratulations to Lab members Ghazaleh Fatemifar and Tom Lumbers for securing a prestigious AHA Data Fellowship to investigate heart failure subtypes using machine learning in heterogenous EHR data.
Many congratulations to Christiana McMahon who successfully defended her thesis and was awarded her PhD on: The evaluation and harmonisation of disparate information metamodels in support of epidemiological and public health research.
Our research using linked primary care and hospital electronic health records from 1.9m patients to study the association of clinically recorded alcohol consumption and the initial presentation of 12 CVDs has just been published in the BMJ and featured in The Guardian and New Scientist. While moderate drinking was associated with a protective effect in terms of some CVD presentations (such as heart attack), the associations observed were overall heterogeneous and varying. This has implications for counselling patients, public health communication, and clinical research, suggesting a more nuanced approach to the role of alcohol in prevention of cardiovascular disease is necessary.
Spiros represented the lab at this year's IEEE BHI conference, hosted in sunny Orlando, Florida. Abstracts from the tea, were presented on a) utilizing phenotyping algorithms derived from electronic health records in order to perform genome wide association studies and b) developing and evaluating a novel probabilistic methods for linking large administrative data from the Brazilian 100 million cohort. Hearty congratulations are due to Clicia and Marcos for winning the best Rapid Fire Presentation / Poster award!
Researchers from the UCL Institute of Health Informatics and Cardiovascular Science in collaboration with other UK and European institutes, were recently awarded €20 million research funding from the European Innovative Medicines Initiative. The research programme, will integrate healthcare data, activity monitors (wearables), state-of-the-art ‘-omics’ profiles, information about patients' lifestyles and health and their own reporting of symptoms, to better understand the causes of heart attack, atrial fibrillation and heart failure. Our lab is co-leading the health informatics work-stream. More details on UCL Press Release.
Congratulations to Maria, Clinical Data Scientist, who has been awarded her PhD from the University of Oxford entitled, "Multiscale modeling of the endothelial glycocalyx in physiological flow: A molecular dynamics approach". (abstract).
The report on the five-year NIHR project that founded CALIBER has been finally published in the NIHR Programme Grants for Applied Research (PGfAR) journal. The report describes the research undertaken in 33 studies using nationwide 'big health data' from linked electronic health records to help improve outcomes in cardiovascular diseases using methods from clinical epidemiology, biomedical informatics, health economics and social science as part of the CALIBER programme. Learn more by visiting the NIHR Journals Library website.