Denaxas Lab

BHIVA 2018

Februrary 2018

Congratulations to Marina Daskalopoulou who had two research abstracts accepted to the British HIV Association 2018 conference: a) Disclosure of HIV-serostatus to new sex partners and sexual behaviours among HIV-diagnosed MSM in the UK: results from the ASTRA study and b) HIV as a risk factor in the initial presentation of a range of cardiovascular, coronary, cerebrovascular, and peripheral arterial diseases: a linked electronic health records study of 8 million adults in the UK.
Funding successes

Februrary 2018

More good news from Maxine Mackintosh who was successful in securitng two research grants: a) from the UCL Grand Challenges Society’s Response to Ageing initiative and b) seed funding from the Doctoral Skills Development Programme Researcher-Led Initiative Award for establishing a Student HealthTech Hub. Well done!
PhD Upgrade: Maxine Mackintosh

January 2018

Congratulations to Maxine Mackintosh who kicked off the new year with a successful PhD upgrade seminar titled How can Primary Care Electronic Health Records facilitate earlier diagnosis of dementia in the prodromal period?. Onwards and upwards!
BHF Immediate PostDoctoral Fellowship

December 2017

Congratulations to Michalis Katsoulis who was awarded a four-year BHF Immediate PostDoctoral Basic Science Research Fellowship on “Weight change and the onset and progression of cardiovascular diseases in large scale electronic health records”. A great way to finish the year!
AMIA 2017 Distinguished Paper Award

November 2017

Our paper Comparing and Contrasting A Priori and A Posteriori Generalizability Assessment of Clinical Trials on Type 2 Diabetes Mellitus won one of the Distinguished Paper Awards of the American Medical Informatics Association 2017 Annual Symposium. Congratulations to Arturo for his great work!.
Denaxas Lab PhD success: Vaclav Papez

October 2017

Many congratulations to Vaclav Papez who successfully defended his thesis and was awarded his PhD on: Archetype-based approach for modelling of electroencephalographic/event-related potentials data and metadata.
Denaxas Lab PhD success: Marina Daskalopoulou

October 2017

Many congratulations to Marina Daskalopoulou who successfully defended her thesis and was awarded her PhD on: Sexual behaviour of HIV-diagnosed men who have sex with men in the current era of effective antiretroviral therapy in the UK.
Wellcome Trust Data Managers Meeting
Kenan Direk represented the Lab and presented our approach to managing and sharing access to linked EHR datasets from the CALIBER platform at the annual Wellcome Trust meeting for data managers. This meeting offered an opportunity for the IT and Data Managers of Wellcome funded programmes, alongside other IT and Data Managers from scientific organisations, to meet each other and discuss best-practices and ideas.
New manuscript: Methods for enhancing the reproducibility of biomedical research findings using electronic health records

September 2017

The ability of external investigators to reproduce published scientific findings is critical for the evaluation and validation of biomedical research by the wider community. However, a substantial proportion of health research using electronic health records (EHR), data collected and generated during clinical care, is potentially not reproducible mainly due to the fact that the implementation details of most data preprocessing, cleaning, phenotyping and analysis approaches are not systematically made available or shared. Our work outlines a collection of methods and tools from adjunct scientific disciplines that can potentially enable the reproducibility of EHR research findings.
American Heart Association (AHA) Institutional Data Fellowship

August 2017

Congratulations to Lab members Ghazaleh Fatemifar and Tom Lumbers for securing a prestigious AHA Data Fellowship to investigate heart failure subtypes using machine learning in heterogenous EHR data.
Denaxas Lab PhD success: Christiana McMahon

May 2017

Many congratulations to Christiana McMahon who successfully defended her thesis and was awarded her PhD on: The evaluation and harmonisation of disparate information metamodels in support of epidemiological and public health research.
New CALIBER paper on alcohol consumption and CVD featured in the news

March 2017

Our research using linked primary care and hospital electronic health records from 1.9m patients to study the association of clinically recorded alcohol consumption and the initial presentation of 12 CVDs has just been published in the BMJ and featured in The Guardian and New Scientist. While moderate drinking was associated with a protective effect in terms of some CVD presentations (such as heart attack), the associations observed were overall heterogeneous and varying. This has implications for counselling patients, public health communication, and clinical research, suggesting a more nuanced approach to the role of alcohol in prevention of cardiovascular disease is necessary.
IEEE International Conference in Biomedical and Health Informatics (BHI-2017)

February 2017

Spiros represented the lab at this year's IEEE BHI conference, hosted in sunny Orlando, Florida. Abstracts from the tea, were presented on a) utilizing phenotyping algorithms derived from electronic health records in order to perform genome wide association studies and b) developing and evaluating a novel probabilistic methods for linking large administrative data from the Brazilian 100 million cohort. Hearty congratulations are due to Clicia and Marcos for winning the best Rapid Fire Presentation / Poster award!
BigData@Heart launch

February 2017

Researchers from the UCL Institute of Health Informatics and Cardiovascular Science in collaboration with other UK and European institutes, were recently awarded €20 million research funding from the European Innovative Medicines Initiative. The research programme, will integrate healthcare data, activity monitors (wearables), state-of-the-art ‘-omics’ profiles, information about patients' lifestyles and health and their own reporting of symptoms, to better understand the causes of heart attack, atrial fibrillation and heart failure. Our lab is co-leading the health informatics work-stream. More details on UCL Press Release.
PhD success, Maria Pikoula (Oxon)

February 2017

Congratulations to Maria, Clinical Data Scientist, who has been awarded her PhD from the University of Oxford entitled, "Multiscale modeling of the endothelial glycocalyx in physiological flow: A molecular dynamics approach". (abstract).
NIHR Programme Grants for Applied Research report published

January 2017

The report on the five-year NIHR project that founded CALIBER has been finally published in the NIHR Programme Grants for Applied Research (PGfAR) journal. The report describes the research undertaken in 33 studies using nationwide 'big health data' from linked electronic health records to help improve outcomes in cardiovascular diseases using methods from clinical epidemiology, biomedical informatics, health economics and social science as part of the CALIBER programme. Learn more by visiting the NIHR Journals Library website.