Journal Articles

• Kuan V, Denaxas S, Gonzalez-Izquierdo A, Direk K, Bhatti O, Husain S, et al. (30-12-2019). A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service. Lancet Digital Health. doi: 10.1016/S2589-7500(19)30012-3.


• Spiros Denaxas, Arturo Gonzalez-Izquierdo, Kenan Direk, Natalie K Fitzpatrick, Ghazaleh Fatemifar, et al. (30-12-2019). UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER. Journal of the American Medical Informatics Association (JAMIA). doi: 10.1093/jamia/ocz105.


• Barbra A. Dickerman, Xabier García-Albéniz, Roger W. Logan, Spiros Denaxas & Miguel A. Hernán (30-12-2019). Avoidable flaws in observational analyses: an application to statins and cancer. Nature Medicine. doi: 10.1038/s41591-019-0597-x.


• Bromage, D.I., Godec, T.R., Pujades-Rodriguez, M. et al. (30-09-2019). Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: a cohort study. Cardiovasc Diabetol. doi: 10.1186/s12933-019-0972-4.


• Uijl A, Koudstaal S, Direk K, Denaxas S, Groenwold RHH, Banerjee A, Hoes AW, Hemingway H, Asselbergs FW (2019). Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records.. Eur J Heart Fail. doi: 10.1002/ejhf.1350.


• Patel RS, Schmidt AF, Tragante V, McCubrey RO, Holmes MV, Howe LJ, Direk K, [...], and Asselbergs FW (2019). Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium.. Circ Genom Precis Med. doi: 10.1161/CIRCGEN.119.002470.


• Patel RS, Schmidt AF, Tragante V, McCubrey RO, Holmes MV, Howe LJ, Direk K, [...], and Asselbergs FW (2019). Association of Chromosome 9p21 with Subsequent Coronary Heart Disease Events: A GENIUS-CHD Study of Individual Participant Data.. Circ Genom Precis Med. doi: 10.1161/CIRCGEN.119.002471.


• Williamson, E., Denaxas, S., Morris, S., Clarke, C. S., Thomas, M., Evans, H., ... & Blackshaw, H. et al. (2019). Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records.. Rhinology. doi: 10.4193/Rhin18.237.


• Blackshaw H., Vennik J., Philpott C., Thomas M., Eyles C., Carpenter J. et al. (2019). Expert panel process to optimise the design of a randomised controlled trial in chronic rhinosinusitis (the MACRO programme). Trials. doi: 10.1186/s13063-019-3318-3.


• Pikoula M., Quint J., Nissen F., Hemingway H., Smeeth L. and Denaxas S. (2019). Identifying clinically important COPD sub-types using data-driven approaches in primary care population based electronic health records. BMC Medical Informatics and Decision Making. doi: 10.1186/s12911-019-0805-0.


• Henry A., Katsoulis M., Masi S., Fatemifar G., Denaxas S., Acosta D., Garfield V., Dale C. (2019). The relationship between sleep duration, cognition and dementia: a Mendelian randomization study. Int J Epidem. doi: 10.1093/ije/dyz071.


• Hingorani A.D., Kuan V., Finan C., Fruger F. A et al. (2019). Improving the odds of drug development success through human genomics: modelling study. Nature Scientific Reports. doi: 10.1038/s41598-019-54849-w.


• Chung SC, Pujades-Rodriguez M, Duyx B, Denaxas SC, Pasea L, Hingorani A, Timmis A, Williams B, Hemingway H (2018). Time spent at blood pressure target and the risk of death and cardiovascular diseases.. PLOS One. doi: 10.1371/journal.pone.0202359.


• Pujades-Rodriguez M, Assi V, Gonzalez-Izquierdo A, Wilkinson T, Schnier C, Sudlow C, Hemingway H, Whiteley WN (2018). The diagnosis, burden and prognosis of dementia: A record-linkage cohort study in England.. PLOS One. doi: 10.1371/journal.pone.0199026.


• Archangelidi O, Pujades-Rodriguez M, Timmis A, Jouven X, Denaxas S, Hemingway H (2018). Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study.. Eur J Prev Cardiol. doi: 10.1177/2047487318785228.


• Gho JMIH, Schmidt AF, Pasea L, Koudstaal S, Pujades-Rodriguez M, Denaxas S, Shah AD, Patel RS, Gale CP, Hoes AW, Cleland JG, Hemingway H, Asselbergs FW (2018). An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors.. BMJ Open. doi: 10.1136/bmjopen-2017-018331.


• Pujades-Rodriguez M, Guttmann OP, Gonzalez-Izquierdo A, Duyx B, O'Mahony C, Elliott P, Hemingway H (2018). Identifying unmet clinical need in hypertrophic cardiomyopathy using national electronic health records.. PLOS One. doi: 10.1371/journal.pone.0191214.


• Wu J, Gale CP, Hall M, Dondo TB, Metcalfe E, Oliver G, Batin PD, Hemingway H, Timmis A, West RM (2018). Editor's Choice - Impact of initial hospital diagnosis on mortality for acute myocardial infarction: A national cohort study.. Eur Heart J Acute Cardiovasc Care. doi: 10.1177/2048872616661693.


• Denaxas S, Direk K, Gonzalez-Izquierdo A, Pikoula M, Cakiroglu A, Moore J, Hemingway H, Smeeth L (2017). Methods for enhancing the reproducibility of biomedical research findings using electronic health records.. BioData Min. doi: 10.1186/s13040-017-0151-7.


• George J, Mathur R, Shah AD, Pujades-Rodriguez M, Denaxas S, Smeeth L, Timmis A, Hemingway H (2017). Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients.. PLOS One. doi: 10.1371/journal.pone.0178945.


• Allan V, Honarbakhsh S, Casas JP, Wallace J, Hunter R, Schilling R, Perel P, Morley K, Banerjee A, Hemingway H (2017). Are cardiovascular risk factors also associated with the incidence of atrial fibrillation? A systematic review and field synopsis of 23 factors in 32 population-based cohorts of 20 million participants.. Thromb Haemost. doi: 10.1160/TH16-11-0825.


• Jordan KP, Timmis A, Croft P, van der Windt DA, Denaxas S, Gonzalez-Izquierdo A, Hayward RA, Perel P, Hemingway H (2017). Prognosis of undiagnosed chest pain: linked electronic health record cohort study.. BMJ. doi: 10.1136/bmj.j1194.


• Bell S, Daskalopoulou M, Rapsomaniki E, George J, Britton A, Bobak M, Casas JP, Dale CE, Denaxas S, Shah AD, Hemingway H (2017). Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records.. BMJ. doi: 10.1136/bmj.j909.


• Shah AD, Thornley S, Chung SC, Denaxas S, Jackson R, Hemingway H (2017). White cell count in the normal range and short-term and long-term mortality: international comparisons of electronic health record cohorts in England and New Zealand.. BMJ Open. doi: 10.1136/bmjopen-2016-013100.


• Koudstaal S, Pujades-Rodriguez M, Denaxas S, Gho JMIH, Shah AD, Yu N, Patel RS, Gale CP, Hoes AW, Cleland JG, Asselbergs FW, Hemingway H (2017). Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people.. Eur J Heart Fail. doi: 10.1002/ejhf.709.


• Pasea L, Chung SC, Pujades-Rodriguez M, Moayyeri A, Denaxas S, Fox KAA, Wallentin L, Pocock SJ, Timmis A, Banerjee A, Patel R, Hemingway H (2017). Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors.. Eur Heart J. doi: 10.1093/eurheartj/ehw683.


• Shah AD, Denaxas S, Nicholas O, Hingorani AD, Hemingway H (2017). Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study.. J Am Coll Cardiol. doi: 10.1016/j.jacc.2016.12.022.


• Allan V, Banerjee A, Shah AD, Patel R, Denaxas S, Casas JP, Hemingway H (2017). Net clinical benefit of warfarin in individuals with atrial fibrillation across stroke risk and across primary and secondary care.. Heart. doi: 10.1136/heartjnl-2016-309910.


• Shah AD, Denaxas S, Nicholas O, Hingorani AD, Hemingway H (2016). Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study.. Open Heart. doi: 10.1136/openhrt-2016-000477.


• Timmis A, Rapsomaniki E, Chung SC, Pujades-Rodriguez M, Moayyeri A, Stogiannis D, Shah AD, Pasea L, Denaxas S, Emmas C, Hemingway H (2016). Prolonged dual antiplatelet therapy in stable coronary disease: comparative observational study of benefits and harms in unselected versus trial populations.. BMJ. doi: 10.1136/bmj.i3163.


• Rothnie KJ, Smeeth L, Pearce N, Herrett E, Timmis A, Hemingway H, Wedzicha J, Quint JK (2016). Predicting mortality after acute coronary syndromes in people with chronic obstructive pulmonary disease.. Heart. doi: 10.1136/heartjnl-2016-309359.


• Pujades-Rodriguez M, Duyx B, Thomas SL, Stogiannis D, Rahman A, Smeeth L, Hemingway H (2016). Rheumatoid Arthritis and Incidence of Twelve Initial Presentations of Cardiovascular Disease: A Population Record-Linkage Cohort Study in England.. PLOS One. doi: 10.1371/journal.pone.0151245.


• Daskalopoulou M, George J, Walters K, Osborn DP, Batty GD, Stogiannis D, Rapsomaniki E, Pujades-Rodriguez M, Denaxas S, Udumyan R, Kivimaki M, Hemingway H (2016). Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men.. PLOS One. doi: 10.1371/journal.pone.0153838.


• Rapsomaniki E, Thuresson M, Yang E, Blin P, Hunt P, Chung SC, Stogiannis D, Pujades-Rodriguez M, Timmis A, Denaxas SC, Danchin N, Stokes M, Thomas-Delecourt F, Emmas C, Hasvold P, Jennings E, Johansson S, Cohen DJ, Jernberg T, Moore N, Janzon M, Hemingway H (2016). Using big data from health records from four countries to evaluate chronic disease outcomes: a study in 114 364 survivors of myocardial infarction.. Eur Heart J Qual Care Clin Outcomes. doi: 10.1093/ehjqcco/qcw004.


• Walker S, Asaria M, Manca A, Palmer S, Gale CP, Shah AD, Abrams KR, Crowther M, Timmis A, Hemingway H, Sculpher M (2016). Long-term healthcare use and costs in patients with stable coronary artery disease: a population-based cohort using linked health records (CALIBER).. Eur Heart J Qual Care Clin Outcomes. doi: 10.1093/ehjqcco/qcw003.


• Asaria M, Walker S, Palmer S, Gale CP, Shah AD, Abrams KR, Crowther M, Manca A, Timmis A, Hemingway H, Sculpher M (2016). Using electronic health records to predict costs and outcomes in stable coronary artery disease.. Heart. doi: 10.1136/heartjnl-2015-308850.


• Pujades-Rodriguez M, Duyx B, Thomas SL, Stogiannis D, Smeeth L, Hemingway H (2016). Associations between polymyalgia rheumatica and giant cell arteritis and 12 cardiovascular diseases.. Heart. doi: 10.1136/heartjnl-2015-308514.


• George J, Rapsomaniki E, Pujades-Rodriguez M, Shah AD, Denaxas S, Herrett E, Smeeth L, Timmis A, Hemingway H (2015). How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People.. Circulation. doi: 10.1161/CIRCULATIONAHA.114.013797.


• Chung SC, Sundstrom J, Gale CP, James S, Deanfield J, Wallentin L, Timmis A, Jernberg T, Hemingway H (2015). Comparison of hospital variation in acute myocardial infarction care and outcome between Sweden and United Kingdom: population based cohort study using nationwide clinical registries.. BMJ. doi: 10.1136/bmj.h3913.


• Dinesh Shah A, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, Deanfield J, Smeeth L, Timmis A, Hemingway H (2015). Type 2 diabetes and incidence of a wide range of cardiovascular diseases: a cohort study in 1.9 million people.. Lancet. doi: 10.1016/S0140-6736(15)60401-9 S0140-6736(15)60401-9 [pii].


• Rubbo B, Fitzpatrick NK, Denaxas S, Daskalopoulou M, Yu N, Patel RS, Hemingway H (2015). Use of electronic health records to ascertain, validate and phenotype acute myocardial infarction: A systematic review and recommendations.. Int J Cardiol. doi: 10.1016/j.ijcard.2015.03.075 S0167-5273(15)00313-7 [pii].


• Brauer R, Smeeth L, Anaya-Izquierdo K, Timmis A, Denaxas SC, Farrington CP, Whitaker H, Hemingway H, Douglas I (2015). Antipsychotic drugs and risks of myocardial infarction: a self-controlled case series study.. Eur Heart J. doi: 10.1093/eurheartj/ehu263.


• Pujades-Rodriguez M, George J, Shah AD, Rapsomaniki E, Denaxas S, West R, Smeeth L, Timmis A, Hemingway H (2015). Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction.. Int J Epidemiol. doi: 10.1093/ije/dyu218.


• Herrett E, Bhaskaran K, Timmis A, Denaxas S, Hemingway H, Smeeth L (2014). Association between clinical presentations before myocardial infarction and coronary mortality: a prospective population-based study using linked electronic records.. Eur Heart J. doi: 10.1093/eurheartj/ehu286.


• Morley KI, Wallace J, Denaxas SC, Hunter RJ, Patel RS, Perel P, Shah AD, Timmis AD, Schilling RJ, Hemingway H (2014). Defining disease phenotypes using national linked electronic health records: a case study of atrial fibrillation.. PLOS One. doi: 10.1371/journal.pone.0110900.


• Pujades-Rodriguez M, Timmis A, Stogiannis D, Rapsomaniki E, Denaxas S, Shah A, Feder G, Kivimaki M, Hemingway H (2014). Socioeconomic deprivation and the incidence of 12 cardiovascular diseases in 1.9 million women and men: implications for risk prediction and prevention.. PLOS One. doi: 10.1371/journal.pone.0104671.


• McNamara RL, Chung SC, Jernberg T, Holmes D, Roe M, Timmis A, James S, Deanfield J, Fonarow GC, Peterson ED, Jeppsson A, Hemingway H (2014). International comparisons of the management of patients with non-ST segment elevation acute myocardial infarction in the United Kingdom, Sweden, and the United States: The MINAP/NICOR, SWEDEHEART/RIKS-HIA, and ACTION Registry-GWTG/NCDR registries.. Int J Cardiol. doi: 10.1016/j.ijcard.2014.04.270 S0167-5273(14)00967-X [pii].


• Shah AD, Bartlett JW, Carpenter J, Nicholas O, Hemingway H (2014). Comparison of random forest and parametric imputation models for imputing missing data using MICE: a CALIBER study.. Am J Epidemiol. doi: 10.1093/aje/kwt312.


• Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, White IR, Caulfield MJ, Deanfield JE, Smeeth L, Williams B, Hingorani A, Hemingway H (2014). Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people.. Lancet. doi: 10.1016/S0140-6736(14)60685-1 S0140-6736(14)60685-1 [pii].


• Chung SC, Gedeborg R, Nicholas O, James S, Jeppsson A, Wolfe C, Heuschmann P, Wallentin L, Deanfield J, Timmis A, Jernberg T, Hemingway H (2014). Acute myocardial infarction: a comparison of short-term survival in national outcome registries in Sweden and the UK.. Lancet. doi: 10.1016/S0140-6736(13)62070-X S0140-6736(13)62070-X [pii].


• Rapsomaniki E, Shah A, Perel P, Denaxas S, George J, Nicholas O, Udumyan R, Feder GS, Hingorani AD, Timmis A, Smeeth L, Hemingway H (2014). Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients.. Eur Heart J. doi: 10.1093/eurheartj/eht533.


• Boggon R, Timmis A, Hemingway H, Raju S, Malvestiti FM, Van Staa TP (2014). Smoking cessation interventions following acute coronary syndrome: a missed opportunity?. Eur J Prev Cardiol. doi: 10.1177/2047487312460517.


• Quint JK, Herrett E, Bhaskaran K, Timmis A, Hemingway H, Wedzicha JA, Smeeth L (2013). Effect of beta blockers on mortality after myocardial infarction in adults with COPD: population based cohort study of UK electronic healthcare records.. BMJ. doi: 10.1136/bmj.f6650 bmj.f6650 [pii].


• Herrett E, Shah AD, Boggon R, Denaxas S, Smeeth L, van Staa T, Timmis A, Hemingway H (2013). Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records: cohort study.. BMJ. doi: 10.1136/bmj.f2350 bmj.f2350 [pii].


• Herrett E, George J, Denaxas S, Bhaskaran K, Timmis A, Hemingway H, Smeeth L (2013). Type and timing of heralding in ST-elevation and non-ST-elevation myocardial infarction: an analysis of prospectively collected electronic healthcare records linked to the national registry of acute coronary syndromes.. Eur Heart J Acute Cardiovasc Care. doi: 10.1177/2048872613487495.


• Warren-Gash C, Hayward AC, Hemingway H, Denaxas S, Thomas SL, Timmis AD, Whitaker H, Smeeth L (2012). Influenza infection and risk of acute myocardial infarction in England and Wales: a CALIBER self-controlled case series study.. J Infect Dis. doi: 10.1093/infdis/jis597.


• Wang Z, Shah AD, Tate AR, Denaxas S, Shawe-Taylor J, Hemingway H (2012). Extracting diagnoses and investigation results from unstructured text in electronic health records by semi-supervised machine learning.. PLOS One. doi: 10.1371/journal.pone.0030412.


• Shah AD, Martinez C, Hemingway H (2012). The freetext matching algorithm: a computer program to extract diagnoses and causes of death from unstructured text in electronic health records.. BMC Med Inform Decis Mak. doi: 10.1186/1472-6947-12-88.


• Douglas IJ, Evans SJ, Hingorani AD, Grosso AM, Timmis A, Hemingway H, Smeeth L (2012). Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs.. BMJ. doi: 10.1136/bmj.e4388 bmj.e4388 [pii].


• Denaxas SC, George J, Herrett E, Shah AD, Kalra D, Hingorani AD, Kivimaki M, Timmis AD, Smeeth L, Hemingway H (2012). Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER).. Int J Epidemiol. doi: 10.1093/ije/dys188.


• Shah AD, Nicholas O, Timmis AD, Feder G, Abrams KR, Chen R, Hingorani AD, Hemingway H (2011). Threshold haemoglobin levels and the prognosis of stable coronary disease: two new cohorts and a systematic review and meta-analysis.. PLOS Med. doi: 10.1371/journal.pmed.1000439.


• Boggon R, van Staa TP, Timmis A, Hemingway H, Ray KK, Begg A, Emmas C, Fox KA (2011). Clopidogrel discontinuation after acute coronary syndromes: frequency, predictors and associations with death and myocardial infarction--a hospital registry-primary care linked cohort (MINAP-GPRD).. Eur Heart J. doi: 10.1093/eurheartj/ehr340.