Amitava Banerjee, Laura Pasea, Sheng-Chia Chung, Kenan Direk, Folkert Asselbergs, Diederick E Grobbee, Dipak Kotecha, Stefan D Anker, Tomasz Dyszynski, Benoı̂t Tyl, others.
A population-based study of 92 clinically recognised risk factors for heart failure.
2024.
Ashkan Dashtban, Mehrdad A Mizani, Laura Pasea, Christopher Tomlinson, Yi Mu, Nazrul Islam, Sarah Rafferty, Charlotte Warren-Gash, Spiros Denaxas, Kim Horstmanshof, others.
Vaccinations, cardiovascular drugs, hospitalization, and mortality in COVID-19 and Long COVID.
International Journal of Infectious Diseases,
2024.
Steven Kerr, Stuart Bedston, Genevieve Cezard, Alexia Sampri, Siobhan Murphy, Declan T Bradley, Kirsty Morrison, Ashley Akbari, William Whiteley, Christopher Sullivan, others.
Undervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Wales.
The Lancet,
2024.
Gary S Collins, Karel GM Moons, Paula Dhiman, Richard D Riley, Andrew L Beam, Ben Van Calster, Marzyeh Ghassemi, Xiaoxuan Liu, Johannes B Reitsma, Maarten Van Smeden, others.
TRIPOD+ AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods.
bmj,
2024.
Harrison Wilde, Christopher Tomlinson, Bilal A Mateen, David Selby, Hari Krishnan Kanthimathinathan, Spiros Denaxas, Seth Flaxman, Sebastian Vollmer, Christina Pagel, Katherine Brown.
Trends in Pediatric Hospital Admissions Caused or Contributed by SARS-CoV-2 Infection in England.
The Journal of Pediatrics,
2024.
Benjamin BD Bray, Daniel O'Connell, Danielle E Robinson, Hannah R Whittaker, John Nolan, Thomas Bolton, Elizabeth I Adesanya, Alison Barnett, Amitava Banerjee, Julia A Critchley, others.
The Impact of the COVID-19 Pandemic on Cardiovascular Risk Factors and Events in England: A Population-Based Cohort Study.
2024.
Mine Koprulu, Eleanor Wheeler, Nicola D Kerrison, Spiros Denaxas, Julia Carrasco-Zanini, Chloe M Orkin, Harry Hemingway, Nicolas J Wareham, Maik Pietzner, Claudia Langenberg.
Similar and different: systematic investigation of proteogenomic variation between sexes and its relevance for human diseases.
medRxiv,
2024.
Neha Pathak, Claire X Zhang, Yamina Boukari, Rachel Burns, Dee Menezes, Gregory Hugenholtz, Rebecca S French, Arturo Gonzalez-Izquierdo, Rohini Mathur, Spiros Denaxas, others.
Sexual and reproductive health and rights of migrant women attending primary care in England: A population-based cohort study of 1.2 million individuals of reproductive age (2009--2018).
Journal of Migration and Health,
2024.
Kirsten Grossmann, Martin Risch, Andjela Markovic, Stefanie Aeschbacher, Ornella C Weideli, Laura Velez, Marc Kovac, Fiona Pereira, Nadia Wohlwend, Corina Risch, others.
Sex-specific differences in physiological parameters related to SARS-CoV-2 infections among a national cohort (COVI-GAPP study).
Plos one,
2024.
Julia Carrasco-Zanini, Maik Pietzner, Jonathan Davitte, Praveen Surendran, Damien C Croteau-Chonka, Chloe Robins, Ana Torralbo, Christopher Tomlinson, Florian Grünschläger, Natalie Fitzpatrick, others.
Proteomic signatures improve risk prediction for common and rare diseases.
Nature medicine,
2024.
Jakob Steinfeldt, Benjamin Wild, Thore Buergel, Maik Pietzner, Julius Upmeier zu Belzen, Andre Vauvelle, Stefan Hegselmann, Spiros Denaxas, Harry Hemingway, Claudia Langenberg, others.
Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats.
Nature Communications,
2024.
Kurt Taylor, Sophie Eastwood, Venexia Walker, Genevieve Cezard, Rochelle Knight, Marwa Al Arab, Yinghui Wei, Elsie mf Horne, Lucy Teece, Harriet Forbes, others.
Incidence of diabetes after SARS-CoV-2 infection in England and the implications of COVID-19 vaccination: a retrospective cohort study of 16 million people.
The Lancet Diabetes & Endocrinology,
2024.
Yen Yi Tan, Wai Hoong Chang, Michail Katsoulis, Spiros Denaxas, Kayla C King, Murray P Cox, Charles Davie, Francois Balloux, Alvina G Lai.
Impact of the COVID-19 pandemic on health-care use among patients with cancer in England, UK: a comprehensive phase-by-phase time-series analysis across attendance types for 38 cancers.
The Lancet Digital Health,
2024.
Daniel S Thayer, Jack Scanlon, Muhammad A Elmessary, Artur Zinnorov, Ieuan Scanlon, Alex Coldea, Hannah Davies, Carla Oliveira, Spiros Denaxas, Emily Jefferson, others.
Evolving the HDRUK Phenotype Library: Phenotype Creation and Editing.
International Journal of Population Data Science,
2024.
Marta Pineda-Moncusı́, Freya Allery, Antonella Delmestri, Thomas Bolton, John Nolan, Johan H Thygesen, Alex Handy, Amitava Banerjee, Spiros Denaxas, Christopher Tomlinson, others.
Ethnicity data resource in population-wide health records: completeness, coverage and granularity of diversity.
Scientific Data,
2024.
Robert W Aldridge, Hannah ER Evans, Alexei Yavlinsky, Alireza Moayyeri, Krishnan Bhaskaran, Rohini Mathur, Kelvin P Jordan, Peter Croft, Spiros Denaxas, Anoop D Shah, others.
Estimating disease burden using national linked electronic health records: a study using an English population-based cohort..
Wellcome Open Research,
2024.
Yvonne Mei Fong Lim, Folkert W Asselbergs, Ayoub Bagheri, Spiros Denaxas, Wan Ting Tay, Adriaan Voors, Carolyn Su Ping Lam, Stefan Koudstaal, Diederick E Grobbee, Ilonca Vaartjes.
Eligibility of Asian and European registry patients for phase III trials in heart failure with reduced ejection fraction.
ESC Heart Failure,
2024.
Marı́a Gordillo-Marañón, Amand F Schmidt, Alasdair Warwick, Chris Tomlinson, Cai Ytsma, Jorgen Engmann, Ana Torralbo, Rory Maclean, Reecha Sofat, Claudia Langenberg, others.
Disease coverage of human genome-wide association studies and pharmaceutical research and development.
Communications Medicine,
2024.
Julian Matthewman, Amy Mulick, Nick Dand, Daniel Major-Smith, Alasdair Henderson, Neil Pearce, Spiros Denaxas, Rita Iskandar, Amanda Roberts, Rosie P Cornish, others.
Disagreement concerning atopic dermatitis subtypes between an English prospective cohort (ALSPAC) and linked electronic health records.
Clinical and Experimental Dermatology,
2024.
Daniel S Thayer, Shahzad Mumtaz, Muhammad A Elmessary, Ieuan Scanlon, Artur Zinnurov, Alex-Ioan Coldea, Jack Scanlon, Martin Chapman, Vasa Curcin, Ann John, others.
Creating a next-generation phenotype library: the health data research UK Phenotype Library.
JAMIA open,
2024.
Praveetha Patalay, Rachel Denholm, Harriet Forbes, Jean Stafford, Bettina Moltrecht, Alex Walker, Tom Palmer, Kurt Taylor, Genevieve Cezard, Elsie mf Horne, others.
COVID-19 and Mental Illnesses in Vaccinated and Unvaccinated People.
JAMA Psychiatry,
2024.
Joshua William Spear, Eleni Pissaridou, Stuart Bowyer, William A Bryant, Daniel Key, John Booth, Anastasia Spiridou, Spiros Denaxas, Rebecca Pope, Andrew M Taylor, others.
Communicating exploratory unsupervised machine learning analysis in age clustering for paediatric disease.
BMJ Health & Care Informatics,
2024.
Samantha Ip, Teri-Louise North, Fatemeh Torabi, Yangfan Li, Hoda Abbasizanjani, Ashley Akbari, Elsie Horne, Rachel Denholm, Spencer Keene, Spiros Denaxas, others.
Cohort study of cardiovascular safety of different COVID-19 vaccination doses among 46 million English adults.
medRxiv,
2024.
Angela Wood, Teri-Louise North, Fatemeh Torabi, Yangfan Li, Hoda Abbasizanjani, Ashley Akbari, Elsie Horne, Rachel Denholm, Spencer Keene, Spiros Denaxas, others.
Cohort study of cardiovascular safety of different COVID-19 vaccination doses among 46 million adults in England.
Nature Research,
2024.
Andrea L Schaffer, Robin Y Park, John Tazare, Krishnan Bhaskaran, Brian MacKenna, Spiros Denaxas, Iain Dillingham, Sebastian CJ Bacon, Amir Mehrkar, Christopher Bates, others.
Changes in sick notes associated with COVID-19 from 2020 to 2022: a cohort study in 24 million primary care patients in OpenSAFELY-TPP.
BMJ open,
2024.
Matthew Barclay, Cristina Renzi, Hannah Harrison, Ana Torralbo, Becky White, Samantha Ip, Juliet Usher-Smith, Jane Lange, Nora Pashayan, Spiros Denaxas, others.
Cancer incidence and competing mortality risk following 15 presenting symptoms in primary care: a population-based cohort study using electronic healthcare records.
medRxiv,
2024.
Colin B Josephson, Eleonora Aronica, Sandor Beniczky, Danielle Boyce, Gianpiero Cavalleri, Spiros Denaxas, Jacqueline French, Lara Jehi, Hyunyong Koh, Patrick Kwan, others.
Big data research is everyone's research-Making epilepsy data science accessible to the global community: Report of the ILAE big data commission.
Epileptic disorders: international epilepsy journal with videotape,
2024.
Ashkan Dashtban, Mehrdad A Mizani, Laura Pasea, Christopher Tomlinson, Yi Mu, Nazrul Islam, Sarah Rafferty, Charlotte Warren-Gash, Spiros Denaxas, Kim Horstmanshof, others.
Association of COVID-19 and influenza vaccinations and cardiovascular pharmacotherapy with hospitalisation and mortality in people with COVID-19 and Long COVID: 2-year follow-up of over 17 million people in England.
2024.
Sara Khalid, Marta Pineda-Moncusı́, Freya Allery, Hoda Abbasizanjani, David Powell, Albert Prats-Uribe, Johan Thygesen, Christopher Tomlinson, Amitava Banerjee, Ashley Akbari, others.
Are ethnic disparities in COVID-19 severe outcomes over? Analysis of 5.3 million individuals in England and Wales from 2020-2022.
2024.
Ana Torralbo, Jonathan M Davitte, Damien C Croteau-Chonka, Cai R Ytsma, Christopher Tomlinson, Natalie Fitzpatrick, Sheng-Chia Chung, Ghazaleh Fatemifar, Adrian S Cortes, Tom G Richardson, others.
A Computational Framework for Defining and Validating Reproducible Phenotyping Algorithms of 313 Diseases in the UK Biobank.
2024.
B Vasey, M Nagendran, B Campbell, DA Clifton, GS Collins, S Denaxas.
& McCulloch, P.(2022).
Reporting guideline for the early stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI. bmj,
2024.
Adeniyi Fagbamigbe, Utkarsh Agrawal, Amaya Azcoaga-Lorenzo, Briana MacKerron, Eda Özyiğit, Daniel C Alexander, Ashley Akbari, Rhiannon K Owen, Jane Lyons, Ronan A Lyons, others.
Clustering Long-Term Health Conditions Among 67728 People with Multimorbidity Using Electronic Health Records in Scotland.
2023.
Mehrdad A Mizani, Ashkan Dashtban, Laura Pasea, Alvina G Lai, Johan Thygesen, Chris Tomlinson, Alex Handy, Jil B Mamza, Tamsin Morris, Sara Khalid, others.
Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19--a data-driven retrospective cohort study.
Journal of the Royal Society of Medicine,
2023.
Vaclav Papez, Maxim Moinat, Erica A Voss, Sofia Bazakou, Anne Van Winzum, Alessia Peviani, Stefan Payralbe, Michael Kallfelz, Folkert W Asselbergs, Daniel Prieto-Alhambra, others.
Transforming and evaluating the UK Biobank to the OMOP Common Data Model for COVID-19 research and beyond.
Journal of the American Medical Informatics Association,
2023.
Jane Lyons, Ashley Akbari, Keith R Abrams, Amaya Azcoaga-Lorenzo, Thamer Ba Dhafari, James Chess, Spiros Denaxas, Richard Fry, Chris P Gale, John Gallacher, others.
Trajectories in chronic disease accrual and mortality across the lifespan in Wales, UK (2005--2019), by area deprivation profile: linked electronic health records cohort study on 965,905 individuals.
The Lancet Regional Health–Europe,
2023.
Caroline E Dale, Rohan Takhar, Raymond Carragher, Michail Katsoulis, Fatemeh Torabi, Stephen Duffield, Seamus Kent, Tanja Mueller, Amanj Kurdi, Thu Nguyen Le Anh, others.
The impact of the COVID-19 pandemic on cardiovascular disease prevention and management.
Nature Medicine,
2023.
Matthew Barclay, Cristina Renzi, Antonis Antoniou, Spiros Denaxas, Hannah Harrison, Samantha Ip, Nora Pashayan, Ana Torralbo, Juliet Usher-Smith, Angela Wood, others.
Phenotypes and rates of cancer-relevant symptoms and tests in the year before cancer diagnosis in UK Biobank and CPRD Gold.
PLOS Digital Health,
2023.
Yinghui Wei, Elsie mf Horne, Rochelle Knight, Genevieve Cezard, Alex Walker, Louis Fisher, Rachel Denholm, Kurt Taylor, Venexia Walker, Stephanie Riley, others.
Patient characteristics associated with clinically coded long COVID: an OpenSAFELY study using electronic health records.
medRxiv,
2023.
M Katsoulis, AG Lai, DK Kipourou, M Gomes, A Banerjee, S Denaxas, RT Lumbers, K Tsilidis, Maria Kostara, A Belot, others.
On the estimation of the effect of weight change on a health outcome using observational data, by utilising the target trial emulation framework.
International Journal of Obesity,
2023.
Samuel JRA Chawner, Amy L Paine, Matt J Dunn, Alice Walsh, Poppy Sloane, Megan Thomas, Alexandra Evans, Lucinda Hopkins-Jones, Siske Struik, IMAGINE-ID consortium, others.
Neurodevelopmental dimensional assessment of young children at high genomic risk of neuropsychiatric conditions.
JCPP Advances,
2023.
Jakob Steinfeldt, Benjamin Wild, Thore Buergel, Maik Pietzner, Julius Upmeier zu Belzen, Andre Vauvelle, Stefan Hegselmann, Spiros Denaxas, Harry Hemingway, Claudia Langenberg, others.
Medical history predicts phenome-wide disease onset.
medRxiv,
2023.
Albert Henry, Xiaodong Mo, Chris Finan, Mark D Chaffin, Doug Speed, Hanane Issa, Spiros Denaxas, James S Ware, Sean L Zheng, Anders Malarstig, others.
Mapping the aetiological foundations of the heart failure spectrum using human genetics.
medRxiv,
2023.
Jemima Scott, Patrick Bidulka, Dominic M Taylor, Udaya Udayaraj, Fergus J Caskey, Kate Birnie, John Deanfield, Mark de Belder, Spiros Denaxas, Clive Weston, others.
Management and outcomes of myocardial infarction in people with impaired kidney function in England.
BMC nephrology,
2023.
Sheng-Chia Chung, Rui Providencia, Reecha Sofat, Mar Pujades-Rodriguez, Ana Torralbo, Ghazaleh Fatemifar, Natalie K Fitzpatrick, Julie Taylor, Ken Li, Caroline Dale, others.
Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals.
Alzheimer’s & Dementia,
2023.
Rhiannon K Owen, Jane Lyons, Ashley Akbari, Bruce Guthrie, Utkarsh Agrawal, Daniel C Alexander, Amaya Azcoaga-Lorenzo, Anthony J Brookes, Spiros Denaxas, Carol Dezateux, others.
Impact on life expectancy of temporal sequencing in a multimorbidity cluster of psychosis, diabetes, and congestive heart failure using linked data for 1.7 million individuals in Wales with 20-year follow-up.
The Lancet Public Health,
2023.
Amitava Banerjee, Ashkan Dashtban, Suliang Chen, Laura Pasea, Johan H Thygesen, Ghazaleh Fatemifar, Benoit Tyl, Tomasz Dyszynski, Folkert W Asselbergs, Lars H Lund, others.
Identifying subtypes of heart failure from three electronic health record sources with machine learning: an external, prognostic, and genetic validation study.
The Lancet Digital Health,
2023.
Ashkan Dashtban, Mehrdad A Mizani, Laura Pasea, Spiros Denaxas, Richard Corbett, Jil B Mamza, He Gao, Tamsin Morris, Harry Hemingway, Amitava Banerjee.
Identifying subtypes of chronic kidney disease with machine learning: development, internal validation and prognostic validation using linked electronic health records in 350,067 individuals.
EBioMedicine,
2023.
Valerie Kuan, Spiros Denaxas, Praveetha Patalay, Dorothea Nitsch, Rohini Mathur, Arturo Gonzalez-Izquierdo, Reecha Sofat, Linda Partridge, Amanda Roberts, Ian CK Wong, others.
Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study.
The Lancet Digital Health,
2023.
Harrison Wilde, Christopher Tomlinson, Bilal A Mateen, David Selby, Hari Krishnan Kanthimathinathan, Padmanabhan Ramnarayan, Pascale Du Pre, Mae Johnson, Nazima Pathan, Arturo Gonzalez-Izquierdo, others.
Hospital admissions linked to SARS-CoV-2 infection in children and adolescents: cohort study of 3.2 million first ascertained infections in England.
bmj,
2023.
Jonathan Kennedy, Michael Parker, Michael Seaborne, Mohamed Mhereeg, Alex Walker, Venexia Walker, Spiros Denaxas, Natasha Kennedy, SV Katikireddi, Sinead Brophy.
Healthcare use attributable to COVID-19: a propensity-matched national electronic health records cohort study of 249,390 people in Wales, UK.
BMC medicine,
2023.
Hoda Abbasizanjani, Fatemeh Torabi, Stuart Bedston, Thomas Bolton, Gareth Davies, Spiros Denaxas, Rowena Griffiths, Laura Herbert, Sam Hollings, Spencer Keene, others.
Harmonising electronic health records for reproducible research: challenges, solutions and recommendations from a UK-wide COVID-19 research collaboration.
BMC Medical Informatics and Decision Making,
2023.
Isabelle Austin-Zimmerman, Daniel F Levey, Olga Giannakopoulou, Joseph D Deak, Marco Galimberti, Keyrun Adhikari, Hang Zhou, Spiros Denaxas, Haritz Irizar, Karoline Kuchenbaecker, others.
Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration.
Nature Communications,
2023.
Sean L Zheng, Albert Henry, Douglas Cannie, Michael Lee, David Miller, Kathryn A McGurk, Isabelle Bond, Xiao Xu, Hanane Issa, Catherine Francis, others.
Genome-wide association analysis reveals insights into the molecular etiology underlying dilated cardiomyopathy.
medRxiv,
2023.
Samantha Ip, Hannah Harrison, Juliet A Usher-Smith, Matthew Barclay, Jonathan Tyrer, Joe Dennis, Xin Yang, Michael Lush, Cristina Renzi, Nora Pashayan, others.
Genetics, primary care records and lifestyle factors for short-term dynamic risk prediction of colorectal cancer: prospective study of asymptomatic and symptomatic UK Biobank participants.
medRxiv,
2023.
Maik Pietzner, Spiros Denaxas, Summaira Yasmeen, Maria Wörheide, Hannah E Schmidt, Burulça Uluvar, Aakash Nepal, Mine Koprulu, Julia Carrasco-Zanini, Matthias Arnold, others.
Genetic architecture and shared mechanisms of common ‘neglected’diseases.
medRxiv,
2023.
Rupa Makadia, Azza Shoaibi, Gowtham A Rao, Anna Ostropolets, Peter R Rijnbeek, Erica A Voss, Talita Duarte-Salles, Juan Manuel Ramı́rez-Anguita, Miguel A Mayer, ́ Filip Maljkovi\, others.
Evaluating the impact of alternative phenotype definitions on incidence rates across a global data network.
JAMIA open,
2023.
Ruth E Costello, John Tazare, Dominik Piehlmaier, Emily Herrett, Edward PK Parker, Bang Zheng, Kathryn E Mansfield, Alasdair D Henderson, Helena Carreira, Patrick Bidulka, others.
Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: a population-based, observational cohort study using the OpenSAFELY platform.
EClinicalMedicine,
2023.
Spiros Denaxas, Jacqueline MacArthur, Sarah Lessels, Matthew Sydes, James Farrell, John Nolan, Lynn Morrice, Dan Thayer, Emily Jefferson, Steffen E Petersen, others.
Ensuring phenotyping algorithms using national electronic health records are FAIR: Meeting the needs of the cardiometabolic research community.
Zenodo,
2023.
F Lucy Wright, Kate Cheema, Raph Goldacre, Nick Hall, Naomi Herz, Nazrul Islam, Zainab Karim, David Moreno-Martos, Daniel R Morales, Daniel O'Connell, others.
Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries.
European Heart Journal-Quality of Care and Clinical Outcomes,
2023.
Rhiannon K Owen, Jane Lyons, Ashley Akbari, Bruce Guthrie, Utkarsh Agrawal, Daniel C Alexander, Amaya Azcoaga-Lorenzo, Anthony J Brookes, Spiros Denaxas, Carol Dezateux, others.
Effect on life expectancy of temporal sequence in a multimorbidity cluster of psychosis, diabetes, and congestive heart failure among 1˙ 7 million individuals in Wales with 20-year follow-up: a retrospective cohort study using linked data.
The Lancet Public Health,
2023.
Kelvin P Jordan, Trishna Rathod-Mistry, Danielle A van der Windt, James Bailey, Ying Chen, Lorna Clarson, Spiros Denaxas, Richard A Hayward, Harry Hemingway, Theocharis Kyriacou, others.
Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study.
European Journal of Preventive Cardiology,
2023.
Erica A Voss, Azza Shoaibi, Lana Yin Hui Lai, Clair Blacketer, Thamir Alshammari, Rupa Makadia, Kevin Haynes, Anthony G Sena, Gowtham Rao, Sebastiaan van Sandijk, others.
Contextualising adverse events of special interest to characterise the baseline incidence rates in 24 million patients with COVID-19 across 26 databases: a multinational retrospective cohort study.
EClinicalMedicine,
2023.
Adeniyi Francis Fagbamigbe, Utkarsh Agrawal, Amaya Azcoaga-Lorenzo, Briana MacKerron, Eda Bilici Özyiğit, Daniel C Alexander, Ashley Akbari, Rhiannon K Owen, Jane Lyons, Ronan A Lyons, others.
Clustering long-term health conditions among 67728 people with multimorbidity using electronic health records in Scotland.
Plos one,
2023.
Sylvia Hartmann, Summaira Yasmeen, Benjamin M Jacobs, Spiros Denaxas, Munir Pirmohamed, Eric R Gamazon, Mark J Caulfield, Genes & Health Research Team, Harry Hemingway, Maik Pietzner, others.
ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon.
Nature Communications,
2023.
Johan H Thygesen, Huayu Zhang, Hanane Issa, Jinge Wu, Tuankasfee Hama, Ana Caterina Phiho Gomes, Tudor Groza, Sara Khalid, Tom Lumbers, Mevhibe Hocaoglu, others.
A nationwide study of 331 rare diseases among 58 million individuals: prevalence, demographics, and COVID-19 outcomes.
medRxiv,
2023.
Keith Siew, Vaksha Patel, Jasminka Zimmermann, Michael Vaughan, Christopher Cheshire, Angela Kubik, Rebecca Finch, Zhongwang Li, Selin Altinok, Willian De Silvera, others.
70 Identifying Subtypes of Chronic Kidney Disease with Machine Learning: Development, Internal Validation and Prognostic Validation Using Electronic Health Records in 350067 Individuals.
QJM: An International Journal of Medicine,
2023.
Ashkan Dashtban, Mehrdad A Mizani, Laura Pasea, Spiros Denaxas, Richard Corbett, Jil Billy Mamza, He Gao, Tamsin Morris, Harry Hemingway, Amitava Banerjee.
Identifying Subtypes of Chronic Kidney Disease with Machine Learning: Development, Internal Validation and Prognostic Validation Using Electronic Health Records in 350067 Individuals.
Internal Validation and Prognostic Validation Using Electronic Health Records in,
2022.
Stefan Thurner, B Christine, BA Barbara, S Zehetmayer, U Wolfgang, M van Smeden, G Heinze, B Van Calster, FW Asselbergs, PE Vardas, others.
A Complex Systems Perspective on Macroprudential Regulation..
Handbook of Financial Stress Testing,
2022.
Mehrdad A Mizani, Muhammad Dashtban, Laura Pasea, Alvina Lai, Johan Hilge Thygesen, Christopher Tomlinson, Alex Handy, Jil Billy Mamza, Tamsin Morris, Sara Khalid, others.
Using National Electronic Health Records for Pandemic Preparedness: Validation of a Parsimonious Model for Predicting Excess Deaths Among Those With COVID-19.
2022.
Spiros Denaxas, Arturo Gonzalez-Izquierdo, Kenan Direk, Natalie K Fitzpatrick, Ghazaleh Fatemifar, Amitava Banerjee, Richard Dobson, Laurence J Howe, Valerie Kuan, R Tom Lumbers, others.
UK phenomics platform for developing and validating EHR phenotypes: CALIBER.
J Am Med Inf,
2022.
Muhammad Dashtban, Mehrdad A Mizani, Spiros Denaxas, Dorothea Nitsch, Jennifer Quint, Richard Corbett, Jil Billy Mamza, Tamsin Morris, Mamas Mamas, Debbie Lawlor, others.
Predicting and Validating Risk of Pre-Pandemic and Excess Mortality in Individuals With Chronic Kidney Disease.
2022.
Vaclav Papez, Maxim Moinat, Erica A Voss, Sofia Bazakou, Anne Van Winzum, Alessia Peviani, Stefan Payralbe, Michael Kallfelz, Folkert W Asselbergs, Daniel Prieto-Alhambra, others.
Transforming and evaluating the UK Biobank to the OMOP Common Data Model for COVID-19 research and beyond.
Journal of the American Medical Informatics Association,
2022.
Caroline E Dale, Rohan Takhar, Ray Carragher, Fatemeh Torabi, Michalis Katsoulis, Stephen Duffield, Seamus Kent, Tanja Mueller, Amanj Kurdi, Stuart McTaggart, others.
The adverse impact of COVID-19 pandemic on cardiovascular disease prevention and management in England, Scotland and Wales: A population-scale descriptive analysis of trends in medication data.
medRxiv,
2022.
Rhiannon Owen, Jane Lyons, Ashley Akbari, Bruce Guthrie, Utkarsh Agrawal, Daniel Alexander, Amaya Azcoaga-Lorenzo, Anthony Brookes, Spiros Denaxas, Carol Dezateux, others.
Temporal sequencing in multimorbidity using population-scale linked data for 1.7 million individuals with 20-year follow-up.
2022.
Samanatha Ip, Fatemeh Torabi, Spiros Denaxas, Ashley Akbari, Hoda Abbasizanjani, Rochelle Knight, Jennifer Anne Cooper, Rachel Denholm, Spencer Keene, Thomas Bolton, others.
Risk of myocarditis and pericarditis following COVID-19 vaccination in England and Wales.
medRxiv,
2022.
Baptiste Vasey, Myura Nagendran, Bruce Campbell, David A Clifton, Gary S Collins, Spiros Denaxas, Alastair K Denniston, Livia Faes, Bart Geerts, Mudathir Ibrahim, others.
Reporting guideline for the early stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI.
bmj,
2022.
Praveen Surendran, Isobel D Stewart, Victoria PW Au Yeung, Maik Pietzner, Johannes Raffler, Maria A Wörheide, Chen Li, Rebecca F Smith, Laura BL Wittemans, Lorenzo Bomba, others.
Rare and common genetic determinants of metabolic individuality and their effects on human health.
Nature Medicine,
2022.
Baptiste Vasey, Myura Nagendran, Bruce Campbell, David A Clifton, Gary S Collins, Spiros Denaxas, Alastair K Denniston, Livia Faes, Bart Geerts, Mudathir Ibrahim, others.
Publisher Correction: Reporting guideline for the early-stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI.
Nature Medicine,
2022.
K Jordan, T Rathod-Mistry, J Bailey, D Van Der Windt, Y Chen, L Clarson, S Denaxas, R Hayward, H Hemingway, T Kyriacou, others.
Prediction of cardiovascular disease in patients with unattributed chest pain in UK primary care.
2022.
M Dashtban, M Mizani, A Gonzalez-Izquierdo, R Corbett, J Quint, S Denaxas, JB Mamza, T Morris, H Hemingway, A Banerjee.
POS-283 HIERARCHICAL CLUSTERING FOR SUBTYPE DISCOVERY OF INCIDENT CHRONIC KIDNEY DISEASE FROM LARGE LONGITUDINAL ELECTRONIC HEALTH RECORDS.
Kidney International Reports,
2022.
F CLEARY, L Kim, DC Wheeler, D Prieto-Merino, R Steenkamp, R Fluck, D Adlam, S Denaxas, K Griffith, F Loud, others.
POS-282 ASSOCIATION BETWEEN PRIMARY CARE CODING OF CHRONIC KIDNEY DISEASE (CKD) AND SUBSEQUENT HOSPITALISATIONS AND DEATH: A COHORT ANALYSIS USING NATIONAL AUDIT DATA.
Kidney International Reports,
2022.
Azza Shoaibi, Gowtham A Rao, Erica A Voss, Anna Ostropolets, Miguel Angel Mayer, Juan Manuel Ramı́rez-Anguita, ́ Filip Maljkovi\, Carevi\' ́Biljana, Scott Horban, Daniel R Morales, others.
Phenotype Algorithms for the Identification and Characterization of Vaccine-Induced Thrombotic Thrombocytopenia in Real World Data: A Multinational Network Cohort Study.
Drug Safety,
2022.
Luı́s Fernando Silva Castro de Araujo, Fanny Cortes, Noêmia Teixeira de Siqueira Filha, Elisângela da Silva Rodrigues, Daiane Borges Machado, Jacyra Azevedo Paiva de Araujo, Glyn Lewis, Spiros Denaxas, Mauricio L Barreto, others.
Patterns of multimorbidity and some psychiatric disorders: A systematic review of the literature.
Frontiers Media,
2022.
Caroline S Clarke, Elizabeth Williamson, Spiros Denaxas, James R Carpenter, Mike Thomas, Helen Blackshaw, Anne GM Schilder, Carl M Philpott, Claire Hopkins, Stephen Morris.
Observational retrospective study calculating health service costs of patients receiving surgery for chronic rhinosinusitis in England, using linked patient-level primary and secondary care electronic data.
BMJ open,
2022.
Jeanne Wolstencroft, Francesca Wicks, Ramya Srinivasan, Sarah Wynn, Tamsin Ford, Kate Baker, Samuel JRA Chawner, Jeremy Hall, Marianne BM van den Bree, Michael J Owen, others.
Neuropsychiatric risk in children with intellectual disability of genetic origin: IMAGINE, a UK national cohort study.
The Lancet Psychiatry,
2022.
Kelvin P Jordan, Trishna Rathod-Mistry, James Bailey, Ying Chen, Lorna Clarson, Spiros Denaxas, Richard A Hayward, Harry Hemingway, Danielle A van der Windt, Mamas A Mamas.
Long-Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study.
Journal of the American Heart Association,
2022.
Martin Risch, Kirsten Grossmann, Stefanie Aeschbacher, Ornella C Weideli, Marc Kovac, Fiona Pereira, Nadia Wohlwend, Corina Risch, Dorothea Hillmann, Thomas Lung, others.
Investigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: An interim analysis of a prospective cohort study (COVI-GAPP).
BMJ open,
2022.
F Lucy Wright, Kate Cheema, Raph Goldacre, Nick Hall, Naomi Herz, Nazrul Islam, Zainab Karim, David Moreno-Martos, Daniel R Morales, Daniel O'Connell, others.
Indirect effects of the first two years of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries..
medRxiv,
2022.
Sheng-Chia Chung, Rui Providencia, Reecha Sofat, Mar Pujades-Rodriguez, Ana Torralbo, Ghazaleh Fatemifar, Natalie K Fitzpatrick, Julie Taylor, Ken Li, Caroline Dale, others.
Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals.
Alzheimer’s & Dementia,
2022.
Amitava Banerjee, Suliang Chen, Muhammad Dashtban, Laura Pasea, Johan H Thygesen, Ghazaleh Fatemifar, Benoit Tyl, Tomasz Dyszynski, Folkert W Asselbergs, Lars Lund, others.
Identifying subtypes of heart failure with machine learning: external, prognostic and genetic validation in three electronic health record sources with 320,863 individuals.
medRxiv,
2022.
Rachel Studer, Claudio Sartini, Kiliana Suzart-Woischnik, Rumjhum Agrawal, Harshul Natani, Simrat K Gill, Sara Bruce Wirta, Folkert W Asselbergs, Richard Dobson, Spiros Denaxas, others.
Identification and mapping real-world data sources for heart failure, acute coronary syndrome, and atrial fibrillation.
Cardiology,
2022.
Caroline S Clarke, Elizabeth Williamson, Spiros Denaxas, James R Carpenter, Mike Thomas, Helen Blackshaw, Anne GM Schilder, Carl Philpott, Claire Hopkins, Stephen Morris.
Healthcare costs for patients receiving surgery for chronic rhinosinusitis in England, using linked primary and secondary care electronic patient-level data.
BMJ Open,
2022.
Jonathan Kennedy, Michael Parker, Michael Seaborne, Mohamed Mhereeg, Alex Walker, Venexia Walker, Spiros Denaxas, Natasha Kennedy, Srinivasa Vittal Katikireddi, Sinead Brophy.
Health care use attributable to COVID-19: A propensity matched national electronic health records cohort study of 249,390 people in Wales, UK.
medRxiv,
2022.
Hoda Abbasizanjani, Fatemeh Torabi, Stuart Bedston, Thomas Bolton, Gareth Davies, Spiros Denaxas, Rowena Griffiths, Laura Herbert, Sam Hollings, Spencer Keene, others.
Harmonising electronic health records for reproducible research: challenges, solutions and recommendations from a UK-wide COVID-19 research collaboration.
2022.
Isabelle Austin-Zimmerman, Daniel F Levey, Olga Giannakopoulou, Joseph D Deak, Marco Galimberti, Hang Zhou, Spiros Denaxas, Haritz Irizar, Karoline Kuchenbaecker, Andrew McQuillin, others.
Genome-wide association study investigating short and long sleep duration: a cross-population meta-analysis.
medRxiv,
2022.
Alex Handy, Amitava Banerjee, Angela M Wood, Caroline Dale, Cathie LM Sudlow, Christopher Tomlinson, Daniel Bean, Johan H Thygesen, Mehrdad A Mizani, Michail Katsoulis, others.
Evaluation of antithrombotic use and COVID-19 outcomes in a nationwide atrial fibrillation cohort.
Heart,
2022.
F Lucy Wright, Kate Cheema, Raph Goldacre, Nick Hall, Naomi Herz, Nazrul Islam, Zainab Karim, David Moreno-Martos, Daniel R Morales, Daniel O'Connell, others.
Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries.
European Heart Journal-Quality of Care and Clinical Outcomes,
2022.
Marta Pineda-Moncusi, Freya Allery, Antonella Delmestri, Thomas Bolton, John Nolan, Johan H Thygesen, Alex Handy, Amitava Banerjee, Spiros Denaxas, Christopher Tomlinson, others.
Digital ethnicity data in population-wide electronic health records in England: a description of completeness, coverage, and granularity of diversity.
medRxiv,
2022.
Maarten Van Smeden, Georg Heinze, Ben Van Calster, Folkert W Asselbergs, Panos E Vardas, Nico Bruining, Peter De Jaegere, Jason H Moore, Spiros Denaxas, Anne-Laure Boulesteix, others.
Critical appraisal of artificial intelligence-based prediction models for cardiovascular disease.
European Heart Journal,
2022.
Johan H Thygesen, Christopher Tomlinson, Sam Hollings, Mehrdad A Mizani, Alex Handy, Ashley Akbari, Amitava Banerjee, Jennifer Cooper, Alvina G Lai, Kezhi Li, others.
COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records.
The Lancet Digital Health,
2022.
Amitava Banerjee, Laura Pasea, Sheng-Chia Chung, Kenan Direk, Folkert Asselbergs, Diederick E Grobbee, Dipak Kotecha, Stefan D Anker, Tomasz Dyszynski, Benoı̂t Tyl, others.
Corrigendum to ‘A population-based study of 92 clinically recognized risk factors for heart failure: co-occurrence, prognosis and preventive potential’[Eur J Heart Fail 2022; 24: 466--480].
European Journal of Heart Failure,
2022.
Dipak Kotecha, Folkert W Asselbergs, Stephan Achenbach, Stefan D Anker, Dan Atar, Colin Baigent, Amitava Banerjee, Birgit Beger, Gunnar Brobert, Barbara Casadei, others.
CODE-EHR best practice framework for the use of structured electronic healthcare records in clinical research.
European heart journal,
2022.
Thomas R Godec, Daniel I Bromage, Mar Pujades-Rodriguez, Antonio Cannatà, Arturo Gonzalez-Izquierdo, Spiros Denaxas, Harry Hemingway, Ajay M Shah, Derek M Yellon, Theresa A McDonagh.
Cardiovascular outcomes associated with treatment of type 2 diabetes in patients with ischaemic heart failure.
ESC Heart Failure,
2022.
Rochelle Knight, Venexia Walker, Samantha Ip, Jennifer A Cooper, Thomas Bolton, Spencer Keene, Rachel Denholm, Ashley Akbari, Hoda Abbasizanjani, Fatemeh Torabi, others.
Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales.
Circulation,
2022.
William N Whiteley, Samantha Ip, Jennifer A Cooper, Thomas Bolton, Spencer Keene, Venexia Walker, Rachel Denholm, Ashley Akbari, Efosa Omigie, Sam Hollings, others.
Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: A population-based cohort study of 46 million adults in England.
PLoS medicine,
2022.
Faye Cleary, Lois Kim, David Prieto-Merino, David Wheeler, Retha Steenkamp, Richard Fluck, David Adlam, Spiros Denaxas, Kathryn Griffith, Fiona Loud, others.
Association between practice coding of chronic kidney disease (CKD) in primary care and subsequent hospitalisations and death: a cohort analysis using national audit data.
BMJ open,
2022.
S Hartmann, S Yasmeen, BM Jacobs, S Denaxas, M Pirmohamed, ER Gamazon, MJ Caulfield, H Hemingway, M Pietzner, C Langenberg, others.
ADRA2AandIRX1are putative risk genes for Raynaud’s phenomenon.
2022.
Ashkan Dashtban, Mehrdad A Mizani, Spiros Denaxas, Dorothea Nitsch, Jennifer Quint, Richard Corbett, Jil B Mamza, Tamsin Morris, Mamas Mamas, Deborah A Lawlor, others.
A retrospective cohort study measured predicting and validating the impact of the COVID-19 pandemic in individuals with chronic kidney disease..
Kidney international,
2022.
Amitava Banerjee, Laura Pasea, Sheng-Chia Chung, Kenan Direk, Folkert W Asselbergs, Diederick E Grobbee, Dipak Kotecha, Stefan D Anker, Tomasz Dyszynski, Benoı̂t Tyl, others.
A population-based study of 92 clinically recognized risk factors for heart failure: co-occurrence, prognosis and preventive potential.
European journal of heart failure,
2022.
Harry Hemingway, Gene S Feder, Natalie K Fitzpatrick, Spiros Denaxas, Anoop D Shah, Adam D Timmis.
Programme grants for applied research.
Using Nationwide Big Datafrom Linked Electronic Health Records to Help Improve Outcomes in Cardiovascular Diseases,
2021.
Robert W Aldridge, Dee Menezes, Dan Lewer, Michelle Cornes, Hannah Evans, Ruth M Blackburn, Richard Byng, Michael Clark, Spiros Denaxas, James Fuller, others.
data in England.[version 1; referees: awaiting peer review].
2021.
José Machado, António Abelha, Manuel Filipe Santos, Filipe Portela, Abdelali Boussadi, Alejandro Rodrı́guez González, Alexandros T Tzallas, Antonio Dourado, Evanthia E Tripoliti, Fabien Scalzo, others.
ISAHealth 2016 Organizing Committee.
2021.
Amitava Banerjee, Laura Pasea, Sinduja Manohar, Alvina G Lai, Eade Hemingway, Izaak Sofer, Michail Katsoulis, Harpreet Sood, Andrew Morris, Caroline Cake, others.
What is the risk to me from COVID-19?: Public involvement in providing mortality risk information for people with high-riskconditions for COVID-19 (OurRisk. CoV).
Clinical Medicine,
2021.
Michail Katsoulis, Bianca D Stavola, Karla Diaz-Ordaz, Manuel Gomes, Alvina Lai, Pagona Lagiou, Goya Wannamethee, Konstantinos Tsilidis, R Thomas Lumbers, Spiros Denaxas, others.
Weight change and the onset of cardiovascular diseases: emulating trials using electronic health records.
Epidemiology (Cambridge, Mass.),
2021.
Deepti Gurdasani, Samir Bhatt, Anthony Costello, Spiros Denaxas, Seth Flaxman, Trisha Greenhalgh, Stephen Griffin, Zoë Hyde, Aris Katzourakis, Martin McKee, others.
Vaccinating adolescents against SARS-CoV-2 in England: a risk--benefit analysis.
Journal of the Royal Society of Medicine,
2021.
Johan H Thygesen, Christopher Tomlinson, Sam Hollings, Mehrdad Mizani, Alex Handy, Ashley Akbari, Amitava Banerjee, Jennifer Cooper, Alvina Lai, Ken Li, others.
Understanding COVID-19 trajectories from a nationwide linked electronic health record cohort of 56 million people: phenotypes, severity, waves & vaccination.
medRxiv,
2021.
John M Dennis, Bilal A Mateen, Raphael Sonabend, Nicholas J Thomas, Kashyap A Patel, Andrew T Hattersley, Spiros Denaxas, Andrew P McGovern, Sebastian J Vollmer.
Type 2 diabetes and COVID-19--Related mortality in the critical care setting: a national cohort study in England, March--July 2020.
Diabetes Care,
2021.
Victoria Garfield, Aliki-Eleni Farmaki, Ghazaleh Fatemifar, Sophie V Eastwood, Rohini Mathur, Christopher T Rentsch, Spiros Denaxas, Krishnan Bhaskaran, Liam Smeeth, Nish Chaturvedi.
The relationship between glycaemia, cognitive function, structural brain outcomes and dementia: A Mendelian randomisation study in the UK Biobank.
Diabetes,
2021.
Isabelle Austin-Zimmerman, Marta Wronska, Baihan Wang, Haritz Irizar, Johan Hilge Thygesen, Anjali Bhat, Spiros Denaxas, Chris Finan, Jasmine Harju-Seppanen, Karoline Kuchenbaecker, others.
The influence of CYP2D6 and CYP2C19 genetic variation on diabetes mellitus risk in people taking antidepressants and antipsychotics..
medRxiv,
2021.
R Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I Swerdlow, Anders Malarstig, Charlotte Andersson, Niek Verweij, Michael V Holmes, others.
The genomics of heart failure: design and rationale of the HERMES consortium.
ESC heart failure,
2021.
Harrison Wilde, Thomas Mellan, Iwona Hawryluk, John M Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal A Mateen, others.
The association between mechanical ventilator availability and mortality risk in intensive care patients with COVID-19: A national retrospective cohort study.
medRxiv,
2021.
Alicia Uijl, Ilonca Vaartjes, Spiros Denaxas, Harry Hemingway, Anoop Shah, John Cleland, Diederick Grobbee, Arno Hoes, Folkert W Asselbergs, Stefan Koudstaal.
Temporal trends in heart failure medication prescription in a population-based cohort study.
BMJ open,
2021.
Jane Lyons, Ashley Akbari, Utkarsh Agrawal, Gill Harper, Amaya Azcoaga-Lorenzo, Rowena Bailey, James Rafferty, Alan Watkins, Richard Fry, Colin McCowan, others.
Protocol for the development of the Wales Multimorbidity e-Cohort (WMC): data sources and methods to construct a population-based research platform to investigate multimorbidity.
BMJ open,
2021.
Ashkan Dashtban, Mehrdad A Mizani, Spiros Denaxas, Dorothea Nitsch, Jennifer Quint, Richard Corbett, Jil Billy Mamza, Tamsin Morris, Mamas Mamas, Deborah A Lawlor, others.
Predicting and validating risk of pre-pandemic and excess mortality in individuals with chronic kidney disease.
2021.
Moawiya Alshunnar, Roy Schwartz, Alasdair Warwick, Abraham Olvera-Barrios, Maria Pikoula, Darren Thomas, Aaron Y Lee, Spiros Denaxas, Catherine Egan, Usha Chakravarthy, others.
Outcomes and risk of reactivation of myopic CNV: Multi-Centre Study with long term follow up.
Investigative Ophthalmology & Visual Science,
2021.
Richard Gale, Claire Gill, Maria Pikoula, Aaron Y Lee, Rachel LW Hanson, Spiros Denaxas, Catherine Egan, Adnan Tufail, Paul Taylor, others.
Multicentre study of 4626 patients assesses the effectiveness, safety and burden of two categories of treatments for central retinal vein occlusion: intravitreal anti-vascular endothelial growth factor injections and intravitreal Ozurdex injections.
British Journal of Ophthalmology,
2021.
Spiros Denaxas, Ge Liu, Qiping Feng, Ghazaleh Fatemifar, Lisa Bastarache, Eric V Kerchberger, Aroon D Hingorani, Tom Lumbers, Josh F Peterson, Wei-Qi Wei, others.
Mapping the Read2/CTV3 controlled clinical terminologies to Phecodes in UK Biobank primary care electronic health records: implementation and evaluation.
AMIA Annual Symposium Proceedings,
2021.
Amitava Banerjee, Suliang Chen, Ghazaleh Fatemifar, Mohamad Zeina, R Thomas Lumbers, Johanna Mielke, Simrat Gill, Dipak Kotecha, Daniel F Freitag, Spiros Denaxas, others.
Machine learning for subtype definition and risk prediction in heart failure, acute coronary syndromes and atrial fibrillation: systematic review of validity and clinical utility.
BMC medicine,
2021.
Angela Wood, Rachel Denholm, Sam Hollings, Jennifer Anne Cooper, Samantha Ip, Venexia Walker, Spiros Denaxas, Ashley Akbari, Jonathan Sterne, Cathie Sudlow, others.
Linking electronic health records for research on a nationwide cohort including over 54 million people in England.
medRxiv,
2021.
Angela Wood, Rachel Denholm, Sam Hollings, Jennifer Cooper, Samantha Ip, Venexia Walker, Spiros Denaxas, Ashley Akbari, Amitava Banerjee, William Whiteley, others.
Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource.
bmj,
2021.
Martin Risch, Kirsten Grossmann, Stefanie Aeschbacher, Ornella C Weideli, Marc Kovac, Fiona Pereira, Nadia Wohlwend, Corina Risch, Dorothea Hillmann, Thomas Lung, others.
Investigation of the Use of a Sensor Bracelet for the Pre-Symptomatic Detection of COVID-19: A National Cohort Study (COVI-Gapp).
2021.
Catherine M Smith, Laura J Shallcross, Peter Dutey-Magni, Anne Conolly, Christopher Fuller, Suzanne Hill, Arnoupe Jhass, Franziska Marcheselli, Susan Michie, Jennifer S Mindell, others.
Incidence, healthcare-seeking behaviours, antibiotic use and natural history of common infection syndromes in England: results from the Bug Watch community cohort study.
BMC infectious diseases,
2021.
Max T Eyre, Rachel Burns, Victoria Kirkby, Catherine Smith, Spiros Denaxas, Vincent Nguyen, Andrew Hayward, Laura Shallcross, Ellen Fragaszy, Robert W Aldridge.
Impact of baseline cases of cough and fever on UK COVID-19 diagnostic testing rates: estimates from the Bug Watch community cohort study-Supplementary material, code and data.
OSF,
2021.
Michail Katsoulis, Alvina Lai, Karla Diaz-Ordaz, Manuel Gomes, Laura Pasea, Amitava Banerjee, Spiros Denaxas, Kostas Tsilidis, Pagona Lagiou, Gesthimani Misirli, others.
Identifying high-risk groups for change in weight and body mass index: population cohort of 11 million measurements in 2.3 million adults.
medRxiv,
2021.
Rachel Studer, Claudio Sartini, Kiliana Suzart-Woischnik, Rumjhum Agrawal, Harshal Natani, Simrat Gill, Sara Bruce Wirta, Folkert Asselbergs, Richard Dobson, Spiros Denaxas, others.
Identification and mapping real-world data sources for heart failure, acute coronary syndrome, and atrial fibrillation.
Cardiology,
2021.
Dan Lewer, Dee Menezes, Michelle Cornes, Ruth M Blackburn, Richard Byng, Michael Clark, Spiros Denaxas, Hannah Evans, James Fuller, Nigel Hewett, others.
Hospital readmission among people experiencing homelessness in England: a cohort study of 2772 matched homeless and housed inpatients.
J Epidemiol Community Health,
2021.
Neha Pathak, Parth Patel, Rachel Burns, Lucinda Haim, Claire X Zhang, Yamina Boukari, Arturo Gonzales-Izquierdo, Rohini Mathur, Caroline Minassian, Alexandra Pitman, others.
Healthcare resource utilisation and mortality outcomes in international migrants to the UK: analysis protocol for a linked population-based cohort study using Clinical Practice Research Datalink (CPRD), Hospital Episode Statistics (HES) and the Office for National Statistics (ONS)[version 2; peer review: 1 approved with reservations, 1 not approved].
Wellcome Open Research,
2021.
PF Dutey-Magni, MJ Gill, D McNulty, G Sohal, A Hayward, L Shallcross, Niall Anderson, Elise Crayton, Gillian Forbes, Arnoupe Jhass, others.
Feasibility study of hospital antimicrobial stewardship analytics using electronic health records.
JAC-Antimicrobial Resistance,
2021.
Amitava Banerjee, Suliang Chen, Laura Pasea, Alvina G Lai, Michail Katsoulis, Spiros Denaxas, Vahe Nafilyan, Bryan Williams, Wai Keong Wong, Ameet Bakhai, others.
Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic.
European journal of preventive cardiology,
2021.
Roy Schwartz, Alasdair Warwick, Abraham Olvera-Barrios, Maria Pikoula, Aaron Y Lee, Spiros Denaxas, Paul Taylor, Catherine Egan, Usha Chakravarthy, Peck Lin Lip, others.
Evolving treatment patterns and outcomes of neovascular age-related macular degeneration over a decade.
Ophthalmology Retina,
2021.
Alex Handy, Amitava Banerjee, Angela Wood, Caroline E Dale, Cathie Sudlow, Christopher Tomlinson, Daniel Bean, Johan H Thygesen, Mehrdad A Mizani, Michail Katsoulis, others.
Evaluation of antithrombotic use and COVID-19 outcomes in a nationwide atrial fibrillation cohort.
medRxiv,
2021.
Michail Katsoulis, Manuel Gomes, Alvina G Lai, Albert Henry, Spiros Denaxas, Pagona Lagiou, Vahe Nafilyan, Ben Humberstone, Amitava Banerjee, Harry Hemingway, others.
Estimating the effect of reduced attendance at emergency departments for suspected cardiac conditions on cardiac mortality during the COVID-19 pandemic.
Circulation: Cardiovascular Quality and Outcomes,
2021.
Neha Pathak, Claire X Zhang, Yamina Boukari, Rachel Burns, Rohini Mathur, Arturo Gonzalez-Izquierdo, Spiros Denaxas, Pam Sonnenberg, Andrew Hayward, Robert W Aldridge.
Development and Validation of a Primary Care Electronic Health Record Phenotype to Study Migration and Health in the UK.
Preprints,
2021.
Martin Chapman, Shahzad Mumtaz, Luke V Rasmussen, Andreas Karwath, Georgios V Gkoutos, Chuang Gao, Dan Thayer, SAIL Databank, Jennifer A Pacheco, Helen Parkinson, others.
Desiderata for the development of next-generation phenotype libraries..
2021.
Valerie Kuan, Helen C Fraser, Melanie Hingorani, Spiros Denaxas, Arturo Gonzalez-Izquierdo, Kenan Direk, Dorothea Nitsch, Rohini Mathur, Constantinos A Parisinos, R Thomas Lumbers, others.
Data-driven identification of ageing-related diseases from electronic health records.
Scientific reports,
2021.
T Rathod-Mistry, M Mamas, J Bailey, Y Chen, L Clarson, S Denaxas, R Hayward, H Hemingway, D Van Der Windt, K Jordan.
Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study.
European Heart Journal,
2021.
Rochelle Knight, Venexia Walker, Samantha Ip, Jennifer A Cooper, Thomas Bolton, Spencer Keene, Rachel Denholm, Ashley Akbari, Hoda Abbasizanjani, Fatemeh Torabi, others.
Association of COVID-19 with arterial and venous vascular diseases: a population-wide cohort study of 48 million adults in England and Wales.
medRxiv,
2021.
William Whiteley, Samantha Ip, Jennifer Anne Cooper, Thomas Bolton, Spencer Keene, Venexia Walker, Rachel Denholm, Ashley Akbari, Efosa Omigie, Sam Hollings, others.
Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, and thrombocytopenic events: whole population cohort study in 46 million adults in England.
medRxiv,
2021.
Roy Schwartz, Alasdair Warwick, Abraham Olvera-Barrios, Maria Pikoula, Aaron Y Lee, Spiros Denaxas, Paul Taylor, Catherine Egan, Usha Chakravarthy, Peck Lin Lip, others.
Are we doing better? Impact of treatment paradigm change on neovascular age-related macular degeneration treatment outcomes over the past decade. A big data analysis..
Investigative Ophthalmology & Visual Science,
2021.
Alvina G Lai, Wai Hoong Chang, Constantinos A Parisinos, Michail Katsoulis, Ruth M Blackburn, Anoop D Shah, Vincent Nguyen, Spiros Denaxas, George Davey Smith, Tom R Gaunt, others.
An Informatics Consult approach for generating clinical evidence for treatment decisions.
medRxiv,
2021.
Timo B Brakenhoff, Billy Franks, Brianna Mae Goodale, Janneke van de Wijgert, Santiago Montes, Duco Veen, Eskild K Fredslund, Theo Rispens, Lorenz Risch, Ariel V Dowling, others.
A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the remote early detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trial.
Trials,
2021.
Amitava Banerjee, Laura Pasea, Sheng-Chia Chung, Kenan Direk, Folkert Asselbergs, Diederick E Grobbee, Dipak Kotecha, Stefan D Anker, Tomasz Dyszynski, Benoı̂t Tyl, others.
A population-based study of 92 clinically recognised risk factors for heart failure: co-occurrence, prognosis and preventive potential.
European journal of heart failure,
2021.
Alex Handy, Angela Wood, Cathie Sudlow, Christopher Tomlinson, Frank Kee, Johan H Thygesen, Mohammad Mamouei, Reecha Sofat, Richard Dobson, Hiu Yan Samantha Ip, others.
A nationwide deep learning pipeline to predict stroke and COVID-19 death in atrial fibrillation.
medRxiv,
2021.
Harrison A Wilde, Thomas A Mellan, Iwona Hawryluk, John Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal A Mateen, others.
A national retrospective cohort study of mechanical ventilator availability and its association with mortality risk in intensive care patients with COVID-19.
medRxiv,
2021.
Samuel JRA Chawner, Joanne L Doherty, Richard JL Anney, Kevin M Antshel, Carrie E Bearden, Raphael Bernier, Wendy K Chung, Caitlin C Clements, Sarah R Curran, Goran Cuturilo, others.
A genetics-first approach to dissecting the heterogeneity of autism: phenotypic comparison of autism risk copy number variants.
American Journal of Psychiatry,
2021.
Neha Pathak, Parth Patel, Rachel Burns, Lucinda Haim, Claire X Zhang, Yamina Boukari, Arturo Gonzales-Izquierdo, Rohini Mathur, Caroline Minassian, Alexandra Pitman, others.
1 approved with reservations, 1 not approved.
2021.
Michail Katsoulis, Bianca DeStavola, Karla Diaz-Ordaz, Manuel Gomes, Alvina Lai, Pagona Lagiou, Goya Wannamethee, Kostas Tsilidis, Tom Lumbers, Spiros Denaxas, others.
Weight change and the incidence of cardiovascular diseases in adults with normal weight, overweight and obesity without chronic diseases; emulating trials using electronic health records.
medRxiv,
2020.
John M Dennis, Bilal A Mateen, Raphael Sonabend, Nicholas J Thomas, Kashyap A Patel, Andrew T Hattersley, Spiros Denaxas, Andrew P McGovern, Sebastian J Vollmer.
Type 2 Diabetes and COVID-19--Related Mortality in the Critical Care Setting: A National Cohort Study in England, March--July 2020.
Diabetes Care,
2020.
Gill Harper, Colin McCowan, John Robson, Chris Holmes, S Denaxas, R Owen, Ann John, Marlous Hall, Chris Leeds Gale, Jan Davies, others.
The Wales Multi-morbidity e-Cohort (WMC): data sources and methods to construct a population-based research platform to investigate multi-morbidity..
2020.
Victoria Garfield, Aliki-Eleni Farmaki, Ghazaleh Fatemifar, Sophie V Eastwood, Rohini Mathur, Christopher T Rentsch, Spiros Denaxas, Krishnan T Bhaskaran, Liam Smeeth, Nish Chaturvedi.
The relationship between glycaemia, cognitive function, structural brain outcomes and dementia: A Mendelian randomization study in the UK Biobank.
medRxiv,
2020.
Simon Ball, Amitava Banerjee, Colin Berry, Jonathan Boyle, Benjamin Bray, William Bradlow, Afzal Chaudhry, Rikki Crawley, John Danesh, Alastair Denniston, others.
The 4C Initiative (Clinical Care for Cardiovascular disease in the COVID-19 pandemic): monitoring the indirect impact of the coronavirus pandemic on services for cardiovascular diseases in the UK.
medRxiv,
2020.
4C Initiative of the CVD-COVID-UK consortium, S Ball, A Banerjee, C Berry, J Boyle, B Bray, W Bradlow, A Chaudhry, R Crawley, J Danesh, others.
The 4C Initiative (Clinical Care for Cardiovascular disease in the COVID-19 pandemic)--monitoring the indirect impact of the coronavirus pandemic on services for cardiovascular diseases in the UK.
medRxiv,
2020.
Alexandre Sepriano, Andreas Kerschbaumer, Josef S Smolen, Désirée Van Der Heijde, Maxime Dougados, Ronald Van Vollenhoven, Iain B McInnes, Johannes W Bijlsma, Gerd R Burmester, Maarten De Wit, others.
Safety of synthetic and biological DMARDs: a systematic literature review informing the 2019 update of the EULAR recommendations for the management of rheumatoid arthritis.
Annals of the rheumatic diseases,
2020.
Richard Gale, Claire Gill, Maria Pikoula, Aaron Y Lee, Rachel LW Hanson, Spiros Denaxas, Catherine Egan, Adnan Tufail, Paul Taylor, others.
Multicentre study of 4626 patients assesses the effectiveness, safety and burden of two categories of treatments for central retinal vein occlusion: intravitreal anti-vascular endothelial growth factor injections and intravitreal Ozurdex injections.
British Journal of Ophthalmology,
2020.
Simon Ball, Amitava Banerjee, Colin Berry, Jonathan R Boyle, Benjamin Bray, William Bradlow, Afzal Chaudhry, Rikki Crawley, John Danesh, Alastair Denniston, others.
Monitoring indirect impact of COVID-19 pandemic on services for cardiovascular diseases in the UK.
Heart,
2020.
Max T Eyre, Rachel Burns, Victoria Kirkby, Catherine Smith, Spiros Denaxas, Vincent Nguyen, Andrew Hayward, Laura Shallcross, Ellen Fragaszy, Robert W Aldridge.
Impact of baseline cases of cough and fever on UK COVID-19 diagnostic testing rates: estimates from the Bug Watch community cohort study.
Wellcome Open Research,
2020.
Spiros Denaxas, A Miguel.
IEA.
International Journal of Epidemiology,
2020.
Michail Katsoulis, Alvina G Lai, Dimitra-Kleio Kipourou, Reecha Sofat, Manuel Gomes, Amitava Banerjee, Spiros Denaxas, Thomas R Lumbers, Kostas Tsilidis, Harry Hemingway, others.
How to estimate the association between change in a risk factor and a health outcome?.
arXiv preprint arXiv:2012.11291,
2020.
Neha Pathak, Parth Patel, Rachel Burns, Lucinda Haim, Claire X Zhang, Yamina Boukari, Arturo Gonzales-Izquierdo, Rohini Mathur, Caroline Minassian, Alexandra Pitman, others.
Healthcare resource utilisation and mortality outcomes in international migrants to the UK: analysis protocol for a linked population-based cohort study using Clinical Practice Research Datalink (CPRD), Hospital Episode Statistics (HES) and the Office for National Statistics (ONS).
Wellcome Open Research,
2020.
Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K Hedman, Jemma B Wilk, Michael P Morley, Mark D Chaffin, others.
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Nature communications,
2020.
Amitava Banerjee, Suliang Chen, Laura Pasea, Alvina Lai, Michail Katsoulis, Spiros Denaxas, Vahe Nafilyan, Bryan Williams, Wai Keong Wong, Ameet Bakhai, others.
Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic..
medRxiv,
2020.
Michail Katsoulis, Manuel Gomes, Alvina G Lai, Albert Henry, Spiros Denaxas, Pagona Lagiou, Vahe Nafilyan, Ben Humberstone, Amitava Banerjee, Harry Hemingway, others.
Estimating the effect of reduced attendance at emergency departments for suspected cardiac conditions on cardiac mortality during the COVID-19 pandemic.
Circulation: Cardiovascular Quality and Outcomes,
2020.
Amitava Banerjee, Laura Pasea, Steve Harris, Arturo Gonzalez-Izquierdo, Ana Torralbo, Laura Shallcross, Mahdad Noursadeghi, Deenan Pillay, Neil Sebire, Chris Holmes, others.
Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study.
The Lancet,
2020.
Alvina G Lai, Laura Pasea, Amitava Banerjee, Geoff Hall, Spiros Denaxas, Wai Hoong Chang, Michail Katsoulis, Bryan Williams, Deenan Pillay, Mahdad Noursadeghi, others.
Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study.
BMJ Open,
2020.
Amitava Banerjee, Michail Katsoulis, Alvina G Lai, Laura Pasea, Thomas A Treibel, Charlotte Manisty, Spiros Denaxas, Giovanni Quarta, Harry Hemingway, Joao Cavalcante, others.
Clinical academic research in the time of Corona: a simulation study in England and a call for action.
medRxiv,
2020.
Samden D Lhatoo, Neda Bernasconi, Ingmar Blumcke, Kees Braun, Jeffrey Buchhalter, Spiros Denaxas, Aristea Galanopoulou, Colin Josephson, Katja Kobow, Daniel Lowenstein, others.
Big data in epilepsy: clinical and research considerations. Report from the Epilepsy Big Data Task Force of the International League Against Epilepsy.
Epilepsia,
2020.
Rochelle Knight, Venexia Walker, Samantha Ip, Jennifer Cooper, Thomas Bolton, Spencer Keene, Rachel Denholm, Ashley Akbari, Hoda Abbasizanjani, Fatemeh Torabi, others.
Association of COVID-19 with major arterial and venous thrombotic diseases: a population-wide.
System,
2020.
Laura Shallcross, Fabiana Lorencatto, Christopher Fuller, Carolyn Tarrant, Jonathan West, Rosanna Traina, Catherine Smith, Gillian Forbes, Elise Crayton, Patrick Rockenschaub, others.
An interdisciplinary mixed-methods approach to developing antimicrobial stewardship interventions: Protocol for the Preserving Antibiotics through Safe Stewardship (PASS) Research Programme.
Wellcome Open Research,
2020.
Harry Hemingway, Ronan Lyons, Qianrui Li, Iain Buchan, John Ainsworth, Jill Pell, Andrew Morris, Michael R Barnes, Helen Bedford, Marion Bennie, others.
A national initiative in data science for health: an evaluation of the UK Farr Institute.
International journal of population data science,
2020.
A Banerjee, L Pasea, SC Chung, K Direk, FW Asselbergs, S Denaxas, H Hemingway.
92 aetiologic factors for heart failure: prevalence, co-occurrence, prognosis and potential for prevention in 170,885 incident HF cases.
European Heart Journal,
2020.
Spiros Denaxas, Arturo Gonzalez-Izquierdo, Kenan Direk, Natalie K Fitzpatrick, Ghazaleh Fatemifar, Amitava Banerjee, Richard JB Dobson, Laurence J Howe, Valerie Kuan, R Tom Lumbers, others.
UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER.
Journal of the American Medical Informatics Association,
2019.
Maurı́cio Lima Barreto, Maria Yury Travassos Ichihara, Bethânia de Araújo Almeida, Marcos Ennes Barreto, L Cabral, Rosemeire Leovigildo Fiaccone, Roberto Perez Carreiro, Carlos Antonio de Souza Teles, Ivan da Rocha Pitta, Gerson Oliveira Penna, others.
The Centre for Data and Knowledge Integration for Health (CIDACS): Linking Health and Social Data in Brazil.
Swansea University,
2019.
Mauricio Lima Barreto, Laura Rodrigues, Spiros Denaxas, George Barbosa, M Sanni Ali, Manoel Barral-Netto, Gerson Penna, Robespierre Pita, Carlos Teles, Roberto P Carreiro, others.
The Center for Data and Knowledge Integration for Health (CIDACS): an experience of linking health and social data in Brazil.
International journal of population data science,
2019.
Amitava Banerjee, Victoria Allan, Spiros Denaxas, Anoop Shah, Dipak Kotecha, Pier D Lambiase, Jacob Joseph, Lars H Lund, Harry Hemingway.
Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records: phenotypes, population prevalence, trends and prognosis.
EP Europace,
2019.
Elizabeth Williamson, Spiros Denaxas, Steve Morris, C Clarke, Mike Thomas, Hannah Evans, Kenan Direk, Arturo Gonzalez-Izquierdo, Paul Little, Valerie Lund, others.
Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records.
Rhinology,
2019.
Amand F Schmidt, Michael V Holmes, David Preiss, Daniel I Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, Dennis Valentine, Zammy Fairhurst-Hunter, others.
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.
BMC cardiovascular disorders,
2019.
Aroon D Hingorani, Valerie Kuan, Chris Finan, Felix A Kruger, Anna Gaulton, Sandesh Chopade, Reecha Sofat, Raymond J MacAllister, John P Overington, Harry Hemingway, others.
Improving the odds of drug development success through human genomics: modelling study.
Scientific Reports,
2019.
Dan Lewer, Dee Menezes, Michelle Cornes, Ruth Blackburn, Richard Byng, Michael Clark, Spiros Denaxas, Hannah Evans, James Fuller, Nigel Hewett, others.
Hospital Readmissions Among People Experiencing Homelessness: A Cohort Study of Linked Hospitalisation and Mortality Data in England for 3,222 Homeless Inpatients.
2019.
Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K Hedman, Jemma B Wilk, Michael P Morley, Mark D Chaffin, others.
Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure.
bioRxiv,
2019.
Jane Vennik, Helen Blackshaw, Carl Philpott, Mike Thomas, Caroline Eyles, James Carpenter, Caroline S Clarke, Stephen Morris, Anne Schilder, Valerie Lund, others.
Expert panel process to optimise the design of a randomised controlled trial in chronic rhinosinusitis (the MACRO programme)..
2019.
Helen Blackshaw, Jane Vennik, Carl Philpott, Mike Thomas, Caroline Eyles, James Carpenter, Caroline S Clarke, Steve Morris, Anne Schilder, Valerie Lund, others.
Expert panel process to optimise the design of a randomised controlled trial in chronic rhinosinusitis (the MACRO programme).
Trials,
2019.
Emelia J Benjamin, Paul Muntner, Alvaro Alonso, Marcio S Bittencourt, Clifton W Callaway, April P Carson, Alanna M Chamberlain, Alexander R Chang, Susan Cheng, Sandeep R Das, others.
Employment Cost Index, Historical Listing--Volume V: Continuous Occupational and Industry Series: September 1975-December 2017. Table 4: employment cost index for total compensation, for civilian workers, by occupation and industry: continuous occupational and industry series..
Circulation,
2019.
Maxine Mackintosh, Rob W Aldridge, Martin Rossor, Arturo Gonzalez-Izquierdo, Kirstie J Whitaker, Elizabeth Ford, Kenan Direk, Spiros Denaxas.
Dementia recognition, diagnosis, and treatment in the UK, 1997--2017: a change-point analysis.
The Lancet,
2019.
Carl Philpott, Steffi Le Conte, David Beard, Jonathan Cook, William Sones, Steve Morris, Caroline S Clarke, Mike Thomas, Paul Little, Jane Vennik, others.
Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial.
Trials,
2019.
Robert W Aldridge, Dee Menezes, Dan Lewer, Michelle Cornes, Hannah Evans, Ruth M Blackburn, Richard Byng, Michael Clark, Spiros Denaxas, James Fuller, others.
Causes of death among homeless people: a population-based cross-sectional study of linked hospitalisation and mortality data in England..
Wellcome open research,
2019.
Laura Pasea, Sheng-Chia Chung, Mar Pujades-Rodriguez, Anoop D Shah, Samantha Alvarez-Madrazo, Victoria Allan, James T Teo, Daniel Bean, Reecha Sofat, Richard Dobson, others.
Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis.
BMC medicine,
2019.
Ruth E Farmer, Rohini Mathur, A Floriaan Schmidt, Krishnan Bhaskaran, Ghazaleh Fatemifar, Sophie V Eastwood, Chris Finan, Spiros Denaxas, Liam Smeeth, Nish Chaturvedi.
Associations between measures of sarcopenic obesity and risk of cardiovascular disease and mortality: a cohort study and Mendelian randomization analysis using the UK Biobank.
Journal of the American Heart Association,
2019.
Claire Hopkins, Elizabeth Williamson, Steve Morris, Caroline S Clarke, Mike Thomas, Hannah Evans, Paul Little, Valerie J Lund, Helen Blackshaw, Anne Schilder, others.
Antibiotic usage in chronic rhinosinusitis: analysis of national primary care electronic health records.
Rhinology,
2019.
Valerie Kuan, Spiros Denaxas, Arturo Gonzalez-Izquierdo, Kenan Direk, Osman Bhatti, Shanaz Husain, Shailen Sutaria, Melanie Hingorani, Dorothea Nitsch, Constantinos A Parisinos, others.
A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service.
The Lancet Digital Health,
2019.
M Pikoula, JK Quint, K Direk, F Nissen, A Gonzalez-Izquierdo, H Hemingway, L Smeeth, S Denaxas.
Discovery of Novel COPD Subtypes Via Cluster Analysis of Clinical Features Extracted from Electronic Health Records.
D13. IMPROVING DIAGNOSIS, CARE QUALITY, AND ADHERENCE IN COPD,
2018.
Steve Harris, Sinan Shi, David Brealey, Niall S MacCallum, Spiros Denaxas, David Perez-Suarez, Ari Ercole, Peter Watkinson, Andrew Jones, Simon Ashworth, others.
Critical Care Health Informatics Collaborative (CCHIC): Data, tools and methods for reproducible research: A multi-centre UK intensive care database.
International Journal of Medical Informatics,
2018.
Johannes MIH Gho, Amand F Schmidt, Laura Pasea, Stefan Koudstaal, Mar Pujades-Rodriguez, Spiros Denaxas, Anoop D Shah, Riyaz S Patel, Chris P Gale, Arno W Hoes, others.
An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors.
BMJ open,
2018.
Kim McGrail, Kerina Jones, Ashley Akbari, Tell Bennett, Andrew Boyd, Fabrizio Carinci, Xinjie Cui, Spiros Denaxas, Nadine Dougall, David Ford, others.
A Position Statement on Population Data Science: The science of data about people.
International Journal of Population Data Science,
2018.
Harry Hemingway, Gene S Feder, Natalie K Fitzpatrick, Spiros Denaxas, Anoop D Shah, Adam D Timmis.
Summary of published papers relating to individual studies in the programme.
Using nationwide �big data�from linked electronic health records to help improve outcomes in cardiovascular diseases: 33 studies using methods from epidemiology, informatics, economics and social science in the ClinicAl disease research using LInked Bespoke studies and Electronic health Records (CALIBER) programme,
2017.
Harry Hemingway, Gene S Feder, Natalie K Fitzpatrick, Spiros Denaxas, Anoop D Shah, Adam D Timmis.
Stable coronary artery disease: risk prediction and cost-effective targeting of interventions.
Using nationwide �big data�from linked electronic health records to help improve outcomes in cardiovascular diseases: 33 studies using methods from epidemiology, informatics, economics and social science in the ClinicAl disease research using LInked Bespoke studies and Electronic health Records (CALIBER) programme,
2017.
Harry Hemingway, Gene S Feder, Natalie K Fitzpatrick, Spiros Denaxas, Anoop D Shah, Adam D Timmis.
Risk factor modification among people without established cardiovascular disease.
Using nationwide �big data�from linked electronic health records to help improve outcomes in cardiovascular diseases: 33 studies using methods from epidemiology, informatics, economics and social science in the ClinicAl disease research using LInked Bespoke studies and Electronic health Records (CALIBER) programme,
2017.
Harry Hemingway, Gene S Feder, Natalie K Fitzpatrick, Spiros Denaxas, Anoop D Shah, Adam D Timmis.
Programme grants for applied research.
Using Nationwide �Big Data�from Linked Electronic Health Records to Help Improve Outcomes in Cardiovascular Diseases,
2017.
Stefan Koudstaal, Mar Pujades-Rodriguez, Spiros Denaxas, Johannes MIH Gho, Anoop D Shah, Ning Yu, Riyaz S Patel, Chris P Gale, Arno W Hoes, John G Cleland, others.
Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people.
European journal of heart failure,
2017.
Clicia Pinto, Robespierre Pita, George Barbosa, Bruno Araújo, Juracy Bertoldo, Samila Sena, Sandra Reis, Rosemeire Fiaccone, Leila Amorim, Maria Yuri Ichihara, others.
Probabilistic integration of large Brazilian socioeconomic and clinical databases.
2017 IEEE 30th International Symposium on Computer-Based Medical Systems (CBMS),
2017.
Laura Pasea, Sheng-Chia Chung, Mar Pujades-Rodriguez, Alireza Moayyeri, Spiros Denaxas, Keith AA Fox, Lars Wallentin, Stuart J Pocock, Adam Timmis, Amitava Banerjee, others.
Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors.
European heart journal,
2017.
Ruth M Blackburn, Andrew Hayward, Michelle Cornes, Martin McKee, Dan Lewer, Martin Whiteford, Dee Menezes, Serena Luchenski, Alistair Story, Spiros Denaxas, others.
Outcomes of specialist discharge coordination and intermediate care schemes for patients who are homeless: analysis protocol for a population-based historical cohort.
BMJ open,
2017.
M Erwood, F Wicks, J Wolstencroft, R Srinivasan, J Hall, M Van den Bree, S Denaxas, D Skuse, ID Imagine, FL Raymond.
Intellectual disability and copy number variants: mental health in the IMAGINE ID cohort.
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH,
2017.
Harry Hemingway, Gene S Feder, Natalie K Fitzpatrick, Spiros Denaxas, Anoop D Shah, Adam D Timmis.
Inequalities in the incidence of 12 cardiovascular diseases across the patient journey.
Using nationwide �big data�from linked electronic health records to help improve outcomes in cardiovascular diseases: 33 studies using methods from epidemiology, informatics, economics and social science in the ClinicAl disease research using LInked Bespoke studies and Electronic health Records (CALIBER) programme,
2017.
A Hingorani, Valerie Kuan, Chris Finan, F Kruger, Anna Gaulton, Sandesh Chopade, Reecha Sofat, R MacAllister, John Overington, Harry Hemingway, others.
Flipping the odds of drug development success through human genomics.
bioRxiv,
2017.
Harry Hemingway, Gene S Feder, Natalie K Fitzpatrick, Spiros Denaxas, Anoop D Shah, Adam D Timmis.
Conclusions and implications for clinical practice and further research.
Using nationwide �big data�from linked electronic health records to help improve outcomes in cardiovascular diseases: 33 studies using methods from epidemiology, informatics, economics and social science in the ClinicAl disease research using LInked Bespoke studies and Electronic health Records (CALIBER) programme,
2017.
Harry Hemingway, Folkert W Asselbergs, John Danesh, Richard Dobson, Nikolaos Maniadakis, Aldo Maggioni, Ghislaine JM van Thiel, Maureen Cronin, Gunnar Brobert, Panos Vardas, others.
Big data from electronic health records for early and late translational cardiovascular research: challenges and potential.
European Heart Journal,
2017.
Steven Bell, Marina Daskalopoulou, Eleni Rapsomaniki, Julie George, Annie Britton, Martin Bobak, Juan P Casas, Caroline E Dale, Spiros Denaxas, Anoop D Shah, others.
Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records.
BMJ,
2017.
Harry Hemingway, Gene S Feder, Natalie K Fitzpatrick, Spiros Denaxas, Anoop D Shah, Adam D Timmis.
Acute myocardial infarction: missed opportunities for treatment during and after hospitalisation.
Using nationwide �big data�from linked electronic health records to help improve outcomes in cardiovascular diseases: 33 studies using methods from epidemiology, informatics, economics and social science in the ClinicAl disease research using LInked Bespoke studies and Electronic health Records (CALIBER) programme,
2017.
Eleni Rapsomaniki, Marcus Thuresson, Erru Yang, Patrick Blin, Phillip Hunt, Sheng-Chia Chung, Dimitris Stogiannis, Mar Pujades-Rodriguez, Adam Timmis, Spiros C Denaxas, others.
Using big data from health records from four countries to evaluate chronic disease outcomes: a study in 114 364 survivors of myocardial infarction.
European Heart Journal-Quality of Care and Clinical Outcomes,
2016.
A Timmis, E Rapsomaniki, SC Chung, M Pujades-Rodriguez, A Moayyeri, D Stogiannis, AD Shah, L Pasea, S Denaxas, C Emmas, others.
Prolonged dual antiplatelet therapy in stable coronary disease: comparative observational study of benefits and harms in unselected versus trial populations.
bmj,
2016.
S Koudstaal, M Pujades-Rodriguez, S Denaxas, JMIH Gho, A Shah, C Gale, A Hoes, J Cleland, F Asselbergs, H Hemingway.
Prognostic burden of heart failure diagnosed in primary care or secondary care: a population-based linked electronic health record cohort study in 2.1 million people: 675.
European Journal of Heart Failure,
2016.
A Moayyeri, R Patel, M Pujades-Rodriguez, S Denaxas, A Banerjee, V Allan, K Direk, D Prieto-Merino, FW Asselbergs, AD Hingorani, others.
Low levels of LDL-cholesterol and incidence of a wide range of cardiovascular diseases: a linked electronic health records cohort of 550,000 people.
2016.
S Denaxas, CP Friedman, A Geissbuhler, H Hemingway, D Kalra, M Kimura, KA Kuhn, TH Payne, FGB de Quiros, JC Wyatt.
Discussion of'Combining Health Data Uses to Ignite Health System Learning'(vol 54, pg 488, 2015).
METHODS OF INFORMATION IN MEDICINE,
2016.
Marina Daskalopoulou, Julie George, Kate Walters, David P Osborn, G David Batty, Dimitris Stogiannis, Eleni Rapsomaniki, Mar Pujades-Rodriguez, Spiros Denaxas, Ruzan Udumyan, others.
Depression as a risk factor for the initial presentation of twelve cardiac, cerebrovascular, and peripheral arterial diseases: data linkage study of 1.9 million women and men.
PloS one,
2016.
Shang-Ming Zhou, Fabiola Fernandez-Gutierrez, Jonathan Kennedy, Roxanne Cooksey, Mark Atkinson, Spiros Denaxas, Stefan Siebert, William G Dixon, Terence W O�Neill, Ernest Choy, others.
Defining disease phenotypes in primary care electronic health records by a machine learning approach: a case study in identifying rheumatoid arthritis.
PloS one,
2016.
Bruna Rubbo, Natalie K Fitzpatrick, Spiros Denaxas, Marina Daskalopoulou, Ning Yu, Riyaz S Patel, UK Biobank Follow-up, Harry Hemingway, Outcomes Working Group, others.
Use of electronic health records to ascertain, validate and phenotype acute myocardial infarction: A systematic review and recommendations.
International journal of cardiology,
2015.
Anoop Dinesh Shah, Claudia Langenberg, Eleni Rapsomaniki, Spiros Denaxas, Mar Pujades-Rodriguez, Chris P Gale, John Deanfield, Liam Smeeth, Adam Timmis, Harry Hemingway.
Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1˙ 9 million people.
The Lancet Diabetes & endocrinology,
2015.
Rachel Johnson, Maggie Evans, Helen Cramer, Kristina Bennert, Richard Morris, Sandra Eldridge, Katy Juttner, Mohammed J Zaman, Harry Hemingway, Spiros Denaxas, others.
Feasibility and impact of a computerised clinical decision support system on investigation and initial management of new onset chest pain: a mixed methods study.
BMC medical informatics and decision making,
2015.
S Denaxas, CP Friedman, Antoine Geissbuhler, H Hemingway, D Kalra, M Kimura, KA Kuhn, HA Payne, FG de Quiros, JC Wyatt.
Discussion of �combining health data uses to ignite health system learning.�.
Methods Inf Med,
2015.
Tito Castillo, Arofan Gregory, Samuel Moore, Brian Hole, Christiana McMahon, Spiros Denaxas, Veerle van Den Eyden, Herve L'Hours, Lucy Bell, Jack Kneeshaw, others.
Wellcome Trust: Enhancing Discoverability of Public Health and Epidemiology Research Data.
Wellcome Trust,
2014.
Eleni Rapsomaniki, Anoop Shah, Pablo Perel, Spiros Denaxas, Julie George, Owen Nicholas, Ruzan Udumyan, Gene Solomon Feder, Aroon D Hingorani, Adam Timmis, others.
Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients.
European heart journal,
2014.
E Rapsomaniki, D Stogiannis, C Emmas, S Chung, L Pasea, S Denaxas, AD Shah, M Pujades-Rodriguez, A Timmis, H Hemingway.
Health outcomes in patients with stable coronary artery disease following myocardial infarction; construction of a PEGASUS-TIMI-54 like population in UK linked electronic health records.
EUROPEAN HEART JOURNAL,
2014.
Katherine I Morley, Joshua Wallace, Spiros C Denaxas, Ross J Hunter, Riyaz S Patel, Pablo Perel, Anoop D Shah, Adam D Timmis, Richard J Schilling, Harry Hemingway.
Defining disease phenotypes using national linked electronic health records: a case study of atrial fibrillation.
PloS one,
2014.
Eleni Rapsomaniki, Adam Timmis, Julie George, Mar Pujades-Rodriguez, Anoop D Shah, Spiros Denaxas, Ian R White, Mark J Caulfield, John E Deanfield, Liam Smeeth, others.
Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1˙ 25 million people.
The Lancet,
2014.
Spiros C Denaxas, Dipak Kalra, Eleni Rapsomaniki, A Shah, Mar Pujades-Rodriguez, Katherine Morley, Adam Timmis, Emily Herrett, Liam Smeeth, Harry Hemingway.
Electronic Health Record Linkages for Translational Cardiovascular Research in Nearly 2 Million People-Clinical Disease Research Using Linked Bespoke Studies and Electronic Records (CALIBER)..
AMIA,
2013.
Emily Herrett, Anoop Dinesh Shah, Rachael Boggon, Spiros Denaxas, Liam Smeeth, Tjeerd van Staa, Adam Timmis, Harry Hemingway.
Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records: cohort study.
BMJ,
2013.
M Asaria, S Walker, MJ Sculpher, S Palmer, A Manca, KR Abrams, H Hemingway, S Denaxas, KI Morley, A Shah, others.
Challenges of conducting economic evaluations using linked electronic health records-CPRD and HES in the United Kingdom.
Value in Health,
2013.
Julie George, Emily Herrett, Spiros Denaxas, Owen Nicholas, Anoop Shah, Eleni Rapsomaniki, Jinqi Zhang, Adam Timmis, Liam Smeeth, Harry Hemingway.
Differential Effects of Smoking on Specific Cardiovascular Presentations in Men and Women: Prospective Cohort Study in 900,000 Patients Using CALIBER Linked Electronic Health Records.
Lippincott Williams & Wilkins,
2012.
Spiros C Denaxas, Julie George, Emily Herrett, Anoop D Shah, Dipak Kalra, Aroon D Hingorani, Mika Kivimaki, Adam D Timmis, Liam Smeeth, Harry Hemingway.
Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER).
International journal of epidemiology,
2012.
Rupak K Banerjee, Arlingstone Khongshei, Tapas Gupta, Ardhendu Banerjee.
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BioMedical Engineering OnLine,
2008.